Newcastle University Drylab/29 May 2008

Mark
Continuing on with coding up algorithm, and collating all biosensor data for the meeting at 2.30.

The CesRK Two-component System

• The most recently two-component system that has been found in Listeria monocytogenes.

• cesK encodes the histidine kinase element

• cesR encodes the response regulator element

• AI – peptide is not clear, literature mining not really helping this – could be the protein coded for at orf2420

The LisK two-component system

• Found early in Listeria monocytogenes

• lisR is the response regulator element

• lisK is the histidine kinase component

• The AI transmitter peptide is encoded in the lisK region and mediates signalling

• Similar system to the one above

• Genbank holds entire two-component system – good potential alternative target to the agr system.

Meeting will commence soon. Need to decide on some further program structure with Matt and Morgan to be coding up over the next couple of days.

Nina
Finished java practise set by morgan for a better understanding of the code I will write up. Designed 10 minute power point presentation of work done so far on individual project. Read key biobrick assembly papers and did summaries. Used Bioinformatics to analyse the Plc/PapR two component system