Team:iHKU
From 2008.igem.org
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Revision as of 21:11, 27 October 2008
The Legend"It all began with the forming of the magic Coli rings. Three were given to the eleven Coli Kings, noblest and fairest of all Coli-beings. Seven were given to the dwarf Colis, great miners who live in there Halls of Agar. And nine, nine rings were given to Mortal Colis, who above all desire power. But they were all of them deceived, for the Dark Coli Lord in secret formed a master Coli ring! One ring rule them all. One by one the Colis fell into the control of Dark Coli Lord. But there were some who resisted it. In a great battle the Dark Coli Lord was ultimately defeated and the Coli rings were lost. Time passes by, history becomes legend, legend becomes myth. When the master Coli ring had passed out from almost all knowledge, it was then picked up by someone who the Colis would never have expected: a group of human from HKU! (Modified from script of The Lord of the Rings: The Fellowship of the Ring)
AbstractThe ability of living organisms to form patterns is an untapped resource for synthetic biology. The HKU iGEM2008 team aims to generate unique patterns by rewiring the genetic circuitry controlling cell motility. Specifically, E. coli cells are programmed to autonomously regulate their movement by sensing local cell density. Interesting patterns are formed by two types of newly engineered cells. The high cell-density motility-off cells spread outwards and spontaneously form a distinctive ring of low cell density surrounded by rings of high cell density whilst the high cell-density motility-on cells form a Fuji-mountain-like structure. Moreover, we build a theoretical model that satisfactorily fits our current experimental data, and also predicts some parameters which may significantly affect the ring formation. The study of this self-organized spatial distribution of cells helps us to understand principles underlying the formation of natural biological patterns, and synthetic non-natural patterns have various potential applied uses
OverviewiGEM2008 iHKU team aims to deliver you the most brilliant project this year. We come from departments of Biochemistry, Bioinformatics, Physics, and Chemistry. With different backgrounds and modalities of thought, we complement each other in developing new ideas, and in following wet/dry lab work (Team).
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