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Lux signaling system
From 2008.igem.org
(New page: == Lux cell signaling system == '''Responsible:''' Andrew Gordon and Pallavi Penumetcha '''Signal molecule:''' ''N''-acyl-homoserine lactone (AHL) Generic term for a variety of species s...) |
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[http://www.nature.com/nature/journal/v434/n7037/full/nature03461.html] A Synthetic multicellular system for programmed pattern formation | [http://www.nature.com/nature/journal/v434/n7037/full/nature03461.html] A Synthetic multicellular system for programmed pattern formation | ||
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Revision as of 14:43, 29 October 2008
Lux cell signaling system
Responsible: Andrew Gordon and Pallavi Penumetcha
Signal molecule: N-acyl-homoserine lactone (AHL) Generic term for a variety of species specific hormone-like molecules
Bacterial species: discovered in Vibrio fischeri known to work in E. coli
Receiver protein: LuxR protein receives signal from AHL; also has some control over transciption of luciferase
Signal molecule synthase: LuxI; also has some control over transciption of luciferase
Additional Information: "Quorum Quenching" aiiA (intracellular) lactonase reduces AHL concentration
Resources
[http://partsregistry.org/Lux Lux Operon Pathway]
[http://partsregistry.org/AHL AHL signaling molecules by species; some are specific to gram pos but may affect gram negs]
[http://www.horizonpress.com/jmmb/v1/v1n1/03.pdf Reducing Crosstalk in Lux System]
References
[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=522112 Quorum Quenching to control Lux Pathway]
[http://www.nature.com/nature/journal/v434/n7037/full/nature03461.html] A Synthetic multicellular system for programmed pattern formation
