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October 21st

During the week:

I was busy with the estimation of parameters in the steady state with four points in the new model with degradation.

This is the new model :

e= alpha * T^m / (K^m+T^m)*(Ki^p+T^p)

so we have 5 parameters (alpha, m, K, p, Ki) to estimate but where as we have just four points from luciferase results we can just estimate four parameters. First I started with estimating alpha,m,K,Ki but couldnt get good results; then I tried alpha,m,K,p and again no improvement. I found out that there is not much sensitivity to alpha but m,K,p and Ki are important so I put some value for alpha and tried to estimate the four rest. Again