Team:Caltech

From 2008.igem.org

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===The large intestine: an ideal bioreactor===
===The large intestine: an ideal bioreactor===
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[[Image:Digestive system diagram en.svg.png|thumb|200px|right|The human digestive tract]]
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Talk about the colon
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===Probiotic bacteria and other natural examples===
===Probiotic bacteria and other natural examples===
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[[Image:Lacbr.jpg|thumb|right|Electron micrograph of ''Lactobacillus brevis'', a probiotic lactic acid bacterium]]
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Talk about probiotics
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===Nissle 1917: Probiotic, commercially available ''E. coli''===
===Nissle 1917: Probiotic, commercially available ''E. coli''===
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[[Image:packshot_mutaflor.jpg|thumb|Mutaflor - q commercially available probiotic ''E. coli'' strain Nissle 1917]]
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[[Image:packshot_mutaflor.jpg|thumb|right|Mutaflor - a commercially available preparation of Nissle 1917]]
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Talk about Nissle 1917
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{{clear}}

Revision as of 21:18, 22 August 2008


 
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iGEM 2008


 
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{{{Content}}}

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The big idea

Engineered gut flora

We aim to engineer a probiotic bacterium to improve its medical applications. Our work focuses on four main areas: (1) pathogen defense, either by expression of pathogen-specific bacteriophage or by targeted bursts of reactive oxygen species; (2) vitamin over-expression and delivery; (3) treatment of lactose intolerance, by preferentially metabolizing lactose and funneling it to vitamin production; and (4) regulation of these three treatment functions to produce subpopulations specialized for each function.

Why engineer gut microbes?

The large intestine: an ideal bioreactor

The human digestive tract

Talk about the colon

Probiotic bacteria and other natural examples

Electron micrograph of Lactobacillus brevis, a probiotic lactic acid bacterium

Talk about probiotics

Nissle 1917: Probiotic, commercially available E. coli

Mutaflor - a commercially available preparation of Nissle 1917

Talk about Nissle 1917

For more details, please see our project page.