Team:Caltech
From 2008.igem.org
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+ | See our wiki at [http://openwetware.org/wiki/IGEM:Caltech/2008 OpenWetWare] | ||
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+ | ==The big idea== | ||
We aim to engineer a probiotic bacterium to improve its medical applications. Our work focuses on four main areas: (1) pathogen defense, either by expression of pathogen-specific bacteriophage or by targeted bursts of reactive oxygen species; (2) vitamin over-expression and delivery; (3) treatment of lactose intolerance, by preferentially metabolizing lactose and funneling it to vitamin production; and (4) regulation of these three treatment functions to produce subpopulations specialized for each function. | We aim to engineer a probiotic bacterium to improve its medical applications. Our work focuses on four main areas: (1) pathogen defense, either by expression of pathogen-specific bacteriophage or by targeted bursts of reactive oxygen species; (2) vitamin over-expression and delivery; (3) treatment of lactose intolerance, by preferentially metabolizing lactose and funneling it to vitamin production; and (4) regulation of these three treatment functions to produce subpopulations specialized for each function. | ||
- | + | ==Why engineer gut microbes?== | |
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+ | ===The large intestine: an ideal bioreactor=== | ||
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+ | ===Probiotic bacteria and other natural examples=== | ||
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+ | ===Nissle 1917: Probiotic, commercially available ''E. coli''=== | ||
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+ | For more details, please see our [[Team:Caltech/Project|project]] page. | ||
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Revision as of 21:33, 21 August 2008
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See our wiki at OpenWetWare The big ideaWe aim to engineer a probiotic bacterium to improve its medical applications. Our work focuses on four main areas: (1) pathogen defense, either by expression of pathogen-specific bacteriophage or by targeted bursts of reactive oxygen species; (2) vitamin over-expression and delivery; (3) treatment of lactose intolerance, by preferentially metabolizing lactose and funneling it to vitamin production; and (4) regulation of these three treatment functions to produce subpopulations specialized for each function. Why engineer gut microbes?The large intestine: an ideal bioreactorProbiotic bacteria and other natural examplesNissle 1917: Probiotic, commercially available E. coliFor more details, please see our project page. |