Team:Imperial College

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<font size="4pt"></html><center>'''<br>For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium ''Bacillus subtilis'' as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.'''<br><br><html></font>
<font size="4pt"></html><center>'''<br>For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium ''Bacillus subtilis'' as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.'''<br><br><html></font>
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<table style="color:#2B48B3;background-color:transparent;"><tr><td><img style="vertical-align:center;" width="380px" src="http://i59.photobucket.com/albums/g305/Timpski/Logo1.png"></td><td style="text-align:right;"><br><i><font size="3pt" style="border:2px solid;padding:7px;"><b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/BioBricks">45 B. subtilis BioBricks submitted!</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;">Pushed for time? <b><a href="https://2008.igem.org/Team:Imperial_College/Summary">Project Summary</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;">Growing Clothes: <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Cellulose">BioCouture</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;">Pushed for time? <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Summary">Project Summary</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;">Growing Clothes: <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Cellulose">BioCouture</a></b></font></i></td></tr></table></html>
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<table style="color:#2B48B3;background-color:transparent;"><tr><td><img style="vertical-align:center;" width="380px" src="http://i59.photobucket.com/albums/g305/Timpski/Logo1.png"></td><td style="text-align:center;"><br><i><font size="3pt" style="border:2px solid;padding:7px;"><b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/BioBricks">45 B. subtilis BioBricks submitted!</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;"><b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Major_Results">BioBrick Characterisation</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;"><b>Chassis Characterisation</b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;">Cell <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Motility">motility tracking</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;">Extensive <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Dry_Lab">modelling</a></b></font></i></td></tr></table></html>
<html><br><hr><center><font size="4pt" style="border:0px solid;padding:10px;">Pushed for time? <b><a href="https://2008.igem.org/Team:Imperial_College/Summary">Project Summary</a></b> | Growing Clothes: <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Cellulose">BioCouture</a></b></font></center><hr></html>
<html><br><hr><center><font size="4pt" style="border:0px solid;padding:10px;">Pushed for time? <b><a href="https://2008.igem.org/Team:Imperial_College/Summary">Project Summary</a></b> | Growing Clothes: <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Cellulose">BioCouture</a></b></font></center><hr></html>
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{{Imperial/Box1|<br>'''<html><font size=6px>Overview</font></html>'''|<br>The principle concepts of the Biofabricator subtilis project are:  
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{{Imperial/Box1|'''<html><font size=6px>Overview</font></html>'''|<html><center><object width="425" height="349"><param name="movie" value="http://www.youtube.com/v/wuHd_4l4u3s&hl=en&fs=1&rel=0&color1=0x006699&color2=0x54abd6&border=1"></param><param name="allowFullScreen" value="true"></param><embed src="http://www.youtube.com/v/wuHd_4l4u3s&hl=en&fs=1&rel=0&color1=0x006699&color2=0x54abd6&border=1" type="application/x-shockwave-flash" allowfullscreen="true" width="425" height="349"></embed></object></center></html>
*First by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location using 3D holography.
*First by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location using 3D holography.
*Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein.
*Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein.

Revision as of 22:46, 29 October 2008



For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.



45 B. subtilis BioBricks submitted!

BioBrick Characterisation

Chassis Characterisation

Cell motility tracking

Extensive modelling



Pushed for time? Project Summary | Growing Clothes: BioCouture


Overview

  • First by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location using 3D holography.
  • Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein.
  • Finally, when our bacteria are stationary in the correct location, the biomaterial production is triggered. These biomaterials can self-assemble to form a 3D bio-scaffold.


Please continue on to our project pages - you may wish to start with our >>> Project Specifications >>>




The Imperial College Team 2008 has received sponsorship from a number of generous companies. We are grateful for their kind support.



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