Team:Imperial College/Chassis 1
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Light is the most obvious candidate, as holography allows us to generate complex patterns with well defined edges in 3D. After examining a number of light sensing pathways, we decided to utilise a native pathway involving YtvA, which is a protein used by ''B. subtilis'' to detect blue light. YtvA triggers a cascade of interactions, but some way down the chain, a molecule called sigma B (σ<sub>B</sub>) is produced. This, in turn, boosts the synthesis of YtvA. | Light is the most obvious candidate, as holography allows us to generate complex patterns with well defined edges in 3D. After examining a number of light sensing pathways, we decided to utilise a native pathway involving YtvA, which is a protein used by ''B. subtilis'' to detect blue light. YtvA triggers a cascade of interactions, but some way down the chain, a molecule called sigma B (σ<sub>B</sub>) is produced. This, in turn, boosts the synthesis of YtvA. | ||
- | We plan to over-express YtvA and use σ<sub>B</sub> as a promoter for genes which stop movement and produce biomaterial. Therefore, when the bacteria detect blue light, those genes will turn on, the bacteria will stop and biomaterial synthesis will begin. <br><br>[http://openwetware.org/wiki/IGEM:IMPERIAL/2008/Prototype/Light '''>>> Details >>>''']|[[Image:Imperial_2008_Hologram_Art. | + | We plan to over-express YtvA and use σ<sub>B</sub> as a promoter for genes which stop movement and produce biomaterial. Therefore, when the bacteria detect blue light, those genes will turn on, the bacteria will stop and biomaterial synthesis will begin. <br><br>[http://openwetware.org/wiki/IGEM:IMPERIAL/2008/Prototype/Light '''>>> Details >>>''']|[[Image:Imperial_2008_Hologram_Art.png |200px | 3D blue holographic image by sculptor Eileen Borgeson[http://www.eileenborgeson.com/default.htm]]}} |
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3D bio-scaffolds are very useful for tissue culture and regenerative medicine, as they offer a suitable 3D enviroment for implanted cells to grow and proliferate. A good analogy would be scaffolding used in the construction industry. Our blue-sky aim is to construct a genetically-engineered machine that can fabricate bio-scaffolds with precise 3D shapes, directed by 3D holography. | 3D bio-scaffolds are very useful for tissue culture and regenerative medicine, as they offer a suitable 3D enviroment for implanted cells to grow and proliferate. A good analogy would be scaffolding used in the construction industry. Our blue-sky aim is to construct a genetically-engineered machine that can fabricate bio-scaffolds with precise 3D shapes, directed by 3D holography. | ||
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- | [http://openwetware.org/wiki/IGEM:IMPERIAL/2008/Prototype/Biomaterials '''>>> Details >>>''']|[[Image:Imperial_2008_Scaffold. | + | [http://openwetware.org/wiki/IGEM:IMPERIAL/2008/Prototype/Biomaterials '''>>> Details >>>''']|[[Image:Imperial_2008_Scaffold.png|right|300px|3D Scaffold]]}} |
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Revision as of 12:46, 20 October 2008
Why B. subtilis?
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