Team:Michigan

From 2008.igem.org

Revision as of 03:08, 27 October 2008 by Alyssade (Talk | contribs)


Michigan iGEM website header.jpg

HOME THE TEAM THE PROJECT REGISTRY PARTS NOTEBOOK


Beauty... and the CLOCK

Circadian Clocking... in E. Coli!

The human body's "clock" regulates the daily cycles of many physiological and metabolic processes, such as the sleep?wake cycle and feeding rhythms. It is controlled by the interplay of numerous molecular factors that orchestrate complex feedback loops and processes that are fundamentally mediated by gene expression and the events that follow it. We are working on constructing a synthetic clock, affectionately deemed "The Sequestilator," that is analogous to the mammalian clock. Our clock consists of two parts: an activator with constitutive expression and a promoter that drives the production of a repressor that binds and "sequesters" the activator away from the promoter. While intuitively it seems that this system may reach a steady state rather than oscillate, simulations have shown that under certain rapid equilibrium and tight binding conditions, this circuit does exhibit oscillations. We are currently involved in building and testing of this device.

Topology

Topology here...


Clock only - no bg small.png




Please refer to our team wiki: HERE. Please refer to our team wiki: HERE.



You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
Example logo.png

Tell us more about your project. Give us background. Use this is the abstract of your project. Be descriptive but concise (1-2 paragraphs)

Your team picture
Team Example 2


(Or you can choose different headings. But you must have a team page, a project page, and a notebook page.)