Team:Paris/First page

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<center><html><div style="color:#275D96; font-size:2em;">Grosse GROSSE Pomme de Terre !</div></html></center>
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<center><html><div style="color:#275D96; font-size:2em;">Grosse GROSSE GROOOOOSSSEEEEE Pomme de Terre !</div></html></center>
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= The BacterioClock =  
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= The BacteriO'Clock =  
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Were you ever dreaming about a new way of thinking everyday life objects ? Be sure .this will come true, under the form of our BacterioClock ! A simple tube which contains the modified bacteria we have created will give you the time, directly from living organisms.
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Have you ever dreamt of a new way of thinking everyday life objects ? Be sure, this will come true, under the form of our BacteriO'Clock ! A simple test tube which contains our modified bacteria will give you the time, directly from living organisms. The hours of the day are color-coded and oscillations ensure the repeated periodic behaviour.
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<embed  width="426" height="320"  src="http://biosynthetique.free.fr/videos/flv_player/flvplayer.swf?autostart=true&amp;repeat&amp;file=http://perso.strepsiade.org/~gvieira/out2.flv" quality="high" type="application/x-shockwave-flash"  allowfullscreen="true" />
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<embed  width="213" height="160"  src="http://biosynthetique.free.fr/videos/flv_player/flvplayer.swf?autostart=true&amp;repeat&amp;file=http://perso.strepsiade.org/~gvieira/out2.flv" quality="high" type="application/x-shockwave-flash"  allowfullscreen="true" align="right"/>
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To achieve this incredible project, we have decided to rely on a genetic structure that allows a specific sequence of lighting (Firt In - First Out behaviour) to occur. The models designed have shown that simply adding a negative feedback from a lighting gene to the first activator will not yield oscillations ! Therefore, we have proposed to induce a necessary delay, through a synchronization process among the population, as represented below :
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To achieve this incredible project, we relied on a well characterized genetic structure that allows a specific sequence of fluorescent proteins expression to occur in a First In - First Out order. This FIFO behaviour enables us to define a rich color encoding of day time. An additional negative feedback loop generates clock oscillations!  
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[[Image:Image_qui_dechire_touuuut|center]]
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More precisely, the oscillations obtained will allow a precise control of the period of our clock. Moreover, thanks to the Biobricks proposed during the iGEM competition, one can imagine to have a self-tuning according to daylight for instance.
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Based on in-depth studies and experimentally measured parameters we develope models that show that this system is not likely to oscillate, and indicate ways to improve the initial design. In particular, this can be achieved by HSL production that enforces a necessary delay and provides an elegant cell synchronization mechanism :
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[[Image:Unimo.png|center|Simple visualization of our color coded BacteriO'Clock]]
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In a nutshell, the new trendy item which will make every biologist in your lab jealous will soon be available. If you manage to wait for the updates, you might even get the version which automatically react to daylight saving time ;)
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In a nutshell, the new trendy item which will make every biologist in your lab jealous will soon be available. Despise a long-cloning period all biobricks and other constructions are now available. Furthermore, we initiated an extensive characterization plan of these parts. If you manage to wait for the updates, you might even get the version which automatically react to daylight saving time ;)

Latest revision as of 01:20, 30 October 2008


Grosse GROSSE GROOOOOSSSEEEEE Pomme de Terre !


The BacteriO'Clock

Have you ever dreamt of a new way of thinking everyday life objects ? Be sure, this will come true, under the form of our BacteriO'Clock ! A simple test tube which contains our modified bacteria will give you the time, directly from living organisms. The hours of the day are color-coded and oscillations ensure the repeated periodic behaviour.

To achieve this incredible project, we relied on a well characterized genetic structure that allows a specific sequence of fluorescent proteins expression to occur in a First In - First Out order. This FIFO behaviour enables us to define a rich color encoding of day time. An additional negative feedback loop generates clock oscillations!

Based on in-depth studies and experimentally measured parameters we develope models that show that this system is not likely to oscillate, and indicate ways to improve the initial design. In particular, this can be achieved by HSL production that enforces a necessary delay and provides an elegant cell synchronization mechanism :

Simple visualization of our color coded BacteriO'Clock

In a nutshell, the new trendy item which will make every biologist in your lab jealous will soon be available. Despise a long-cloning period all biobricks and other constructions are now available. Furthermore, we initiated an extensive characterization plan of these parts. If you manage to wait for the updates, you might even get the version which automatically react to daylight saving time ;)