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Team:Paris/Network analysis and design/Core system/Model construction/Detailed justification
From 2008.igem.org
- Detailed justification
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We shall present here a more detailed presentation of the choice we made as far as our model is concerned
Contents |
Sum effect and linear modelling
- Yet, the flagella gene network has been thoroughly studied in [1]. We used two major results presented in this study. Firstly, Shiraz Kalir and Uri Alon came up with the fact that the promoters of class 2 genes, among which fliL, flgA and flhB, behaved like SUM-gate functions with flhDC and fliA inputs. Secondly, their experiments proved that these influences could be considered as linear. Thus the following model:
β and β’ represent the relative influence of flhDC and fliA respectively, the units of β and β’ being time-1.
- Furthermore, they came up with numerical values of β and β’ for each gene, which fitted quite well to their experiments. We then decided that we could use those values as well in our model.
