Team:Paris/Project
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== FIFO == | == FIFO == | ||
- | First In First Out (FIFO) systems are present everywhere | + | First In First Out (FIFO) systems are present everywhere from flux management or electronics to genetic networks. It is interesting in any process that requires several steps in a defined order. FIFO behaviour indeed prevents from needlessly performing the first steps while the last ones are OFF. |
If you want to make French fries you need to produce potatoes before you can cut them and you need to cut them before frying them. But it would be a waste to continue producing potatoes if you've already turned off the fryer :-) You would accumulate unprocessed intermediates! | If you want to make French fries you need to produce potatoes before you can cut them and you need to cut them before frying them. But it would be a waste to continue producing potatoes if you've already turned off the fryer :-) You would accumulate unprocessed intermediates! |
Revision as of 13:15, 25 October 2008
SummaryOur project aims at biologically devising a “oscillating FIFO behaviour, synchronized at population level”. Such a setup will trigger periodic events and,therefore, can be considered as a “biological clock”. To completely deserve this appellation, the system has to fulfill the following specifications :
We will base our project on an already existing structure, partly fulfilling the evoked specifications: the system that leads to the production of E. coli flagella.
MotivationsFIFOFirst In First Out (FIFO) systems are present everywhere from flux management or electronics to genetic networks. It is interesting in any process that requires several steps in a defined order. FIFO behaviour indeed prevents from needlessly performing the first steps while the last ones are OFF. If you want to make French fries you need to produce potatoes before you can cut them and you need to cut them before frying them. But it would be a waste to continue producing potatoes if you've already turned off the fryer :-) You would accumulate unprocessed intermediates! The same goes for the bacterium flagella. To be efficient they naturally need to produce the proteins of the base first. But when you stop making flagella, the base proteins are also the first thing you need to stop producing. It has been proposed (Alon, ...) that the gene network controlling the production of E.coli flagellum behaves as a FIFO. We thus decided to use this regulatory network to implement our FIFO. For a detailed description of E.Coli flagellum regulatory network, please go here OscillationsOscillating FIFOThe 3 Modules |