From 2008.igem.org
Overall project
Mechanical forces are generated in the cell during processes as diverse as chromosomal segregation, replication, transcription, translation, translocation of proteins across membranes, cell locomotion, and catalyzed protein and nucleic acid folding and unfolding, among others as protein folding, DNA elasticity, the protein-induced bending of DNA and the nduced catalysis of enzymes. Our objetive is to understand the role of mechanical force in biochemistry.
Project Details
References
- Chemla, Y.R., Moffitt, J.R., and C. Bustamante, Exact Solutions for Kinetic Models of Macromolecular Dynamics. J. Phys. Chem. B 112(19), 6025 -6044 (2008)
- Bustamante C, Liphardt J, Ritort F. The nonequilibrium thermodynamics of small systems. Physics Today 58 (7): 43-48 JUL (2005).
- Bustamante C, Chemla YR, Forde NR & Izhaky D . Mechanical processes in biochemistry. Annual Review of Biochemistry (2004) 73: 705-748.
- Bustamante C, Bryant Z, Smith SB. Ten years of tension: single-molecule DNA mechanics. Nature (2003) 421: 423 - 427
Results
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