Team:Tsinghua

From 2008.igem.org

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                      '''Internationally Genetically Engineered Machine Competition'''
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<div style="background-color:#d2fcd9; color:#d2fcd9">
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'''Main Page'''       
 
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'''Our Team'''     
 
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'''Project '''   
 
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'''Modeling '''     
 
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'''Laboratory Work '''   
 
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'''Parts'''       
 
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'''Communication''' 
 
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'''Doodle Board'''
 
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[[Image:Girls' Day 4.jpg]] 
 
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{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="100%" align="center"
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!align="center"|[[Team:Tsinghua|HOME]]
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[[Our Team]]
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!align="center"|[[Team:Tsinghua/Team|Team]]
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!align="center"|[[Team:Tsinghua/Project|Project 1]]
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!align="center"|[[Team:Tsinghua/Project2|Project 2]]
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!align="center"|[[Team:Tsinghua/Parts|Parts]]
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!align="center"|[[Team:Tsinghua/Modelling|Modelling]]
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!align="center"|[[Team:Tsinghua/Notebook|Notebook]]
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!align="center"|[[Team:Tsinghua/Doodle|Doodle Board]]
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|}
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<br>
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[[Image:554.jpg|center|]]
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<br>
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=Our ideas=
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  == Team Roster ==
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====Poor Driver In a Strange Car====
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Guoqiang Chen Professor chengq@mail.tsinghua.edu.cn
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The car is strange because it can only run forward or tumble. The probability of the two states is controlled through a handle in it. Even worth, there are no windows on this car but a barometer showing local altitude. How should the driver do to reach the top of the hill and stay at there?
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Shao Li Professor shaoli@tsinghua.edu.cn
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...
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Zhirong Sun Professor sunzhr@mail.tsinghua.edu.cn
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If you think about the design of bacterial chemotaxis pathway, you will find that this pathway just plays the role of the driver in the story above. Interestingly, we find E. coli chemotaxis pathway realizes this delicate dicision-making process through the interactions amount handful molecules. Our project will show how we learn the design principles from native pathway to complete our device.
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Syna Gao Ph.D         synagao@gmail.com
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|<html><object width="425" height="350"> <param name="movie"value="http://www.youtube.com/v/EfY4RTA93ME"</center> </param> <embed src="http://www.youtube.com/v/EfY4RTA93ME" type="application/x-shockwave-flash" width="425" height="350"></embed></object></html>
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Tao  Ma Ph.D         mat07@mails.thu.edu.cn
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Yanchao Han Ph.D         haytcb@gmail.com
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Feng Liu Undergraduate liufeng04@mails.tsinghua.edu.cn
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Junjie Luo Undergraduate jjluo54@163.com
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=Introduction of Tsinghua University=
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Yaxuan Yang Undergraduate yangyx04@mails.tsinghua.edu.cn
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Jun Wang Undergraduate wj-cn@163.com
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Chao Wang Undergraduate wangchao05@mails.tsinghua.edu.cn
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|Tsinghua University was established in 1911, originally under the name “Tsinghua Xuetang”. The school was renamed "Tsinghua School" in 1912. The university section was founded in 1925. The name “National Tsinghua University” was adopted in 1928.[[gallery|click here to see more pictures]]
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Qi  Liu Undergraduate q-liu05@mails.tsinghua.edu.cn
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Shiqing Wang Undergraduate wangsq05@mails.thu.edu.cn
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Tong  Si Undergraduate sit05@mails.thu.edu.cn
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Shan Lin Undergraduate coolls03@163.com
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Yilong Zou Undergraduate ylzouyilong@yahoo.cn
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Ziying Liu Undergraduate liuzy05@mails.tsinghua.edu.cn
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Xing Rong Undergraduate rongx05@mails.thu.edu.cn
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Yicheng Long Undergraduate longyc05@mails.tsinghua.edu.cn
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Luying Jia Undergraduate jialy05@mails.tsinghua.edu.cn
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Yuemeng Wang Undergraduate wym05@mails.tsinghua.edu.cn
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Junya Peng Undergraduate junya.peng@gmail.com
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Xiaoxi Yuan Undergraduate tangbf1983@gmail.com
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Chong Wang Undergraduate wangchongxn@yahoo.com.cn
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Feng  Tian Undergraduate tianf06@mails.tsinghua.edu.cn
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Yuanfan  Yang Undergraduate yangyf06@mails.tsinghua.edu.cn
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Liang Zheng Undergraduate 1000zhengliang@sina.com
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Yongqiang Gou Undergraduate gouyongqiang007@163.com
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He  Yang Undergraduate yanghemary@gmail.com
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Zi  Wang Undergraduate fiona99988@yahoo.com.cn
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Gechong  Ruan    Undergraduate  rgc06@mails.tsinghua.edu.cn
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Bing  Xing      Undergraduate  binxing1987@gmail.com
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The educational philosophy of Tsinghua is to "train students with integrity." Among over 120,000 students who have graduated from Tsinghua since its founding are many outstanding scholars, eminent entrepreneurs and great statesmen remembered and respected by their fellow Chinese citizens.
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  == Team Members ==
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With the motto of “Self-Discipline and Social Commitment” and the spirit of “Actions Speak Louder than Words”, Tsinghua University is dedicated to the well-being of Chinese society and to world development.
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    Junjie Luo          Yaxuan Yan                  Jun Wang
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  Chao Wang      Qi Liu    Shiqing Wang              Tong Si
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|[[image:thu_1.jpg|right]]
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|}
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  Shan Lin          Yilong Zou          Ziying Liu                  Xin Rong
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=News=
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  Jamboree is coming in 8 days!
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  Yicheng Long      Luying Jia    Yuemeng Wang   Junya Peng
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   Tsinghua team, Beijing_Normal team, USTC team will lodge together during the Jamboree.
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  last edit by [[User:Ylzouyilong|Ylzouyilong]] Oct 29.2008
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  Xiaoxi Yuan    Chong Wang    Feng Tian  Yuanfan Yang 
 
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  Liang Zheng    Yongqiang Gou  He Yang
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= Communication =
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    Zi Wang    Gechong Ruan      Bing Xing
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[[ Communication and Interaction ]]
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= Acknowledgement =
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[[Image:Tsinghua.gif]][[Image:Biobricks.png]][[Image:SB4.0.gif]][[Image:invitrogen.jpg]][[Image:mathwork.jpg]][[Image:geneart.gif]][[Image:DSM3.GIF]]
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{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="100%" align="center"
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!align="center"|[[Team:Tsinghua|HOME]]
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!align="center"|[[Team:Tsinghua/Team|Team]]
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!align="center"|[[Team:Tsinghua/Project|Project 1]]
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!align="center"|[[Team:Tsinghua/Project2|Project 2]]
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!align="center"|[[Team:Tsinghua/Parts|Parts]]
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!align="center"|[[Team:Tsinghua/Modelling|Modelling]]
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!align="center"|[[Team:Tsinghua/Notebook|Notebook]]
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!align="center"|[[Team:Tsinghua/Doodle|Doodle Board]]
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|}
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<!--- The Mission, Experiments --->
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[[image:06.jpeg|center|]]
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  == Our Schedule ==
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== Headline text ==
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[[Project]]
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  == Introduction ==
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      Motile bacteria can respond to chemical gradients in their environment. Such directed movement in response to
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special chemicals is defined as chemotaxis.
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If organisms detect substances beneficial for surviving, positive chemotaxis occurs and cells will move in the direction of increasing concentration. In contrast, negative chemotaxis occurs when motile bacteria move away from a repellant. Both kinds of responses adjust the behaviors of organisms to the environment, thus improve their ability of surviving.
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One typical chemotactic behavior is the response of Escherichia coli toward certain nutritions, which plays a key role in seeking food. Researchers have investigated thoroughly into the molecular mechanism of it.
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Motility in prokaryotes is accomplished by flagellum, a complex structure moving the cell by rotation, much like the propeller in a motor boat. In E.coli, counterclockwise rotation moves the cell in a direction called a run, while clockwise rotation results in tumbling of the cell.
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The direction of rotation is controlled by phosphorylation of CheY, a signaling protein in the chemotaxis pathway of E.coli. Low level of phosphorylation results in counterclockwise rotation of flagella and makes the cell move forward. In contrast, phosphorylated CheY favors tumbling.
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The level of protein phosphorylation is regulated by certain attractant or repellent, which can bind specific receptors on the cell surface. Signals are then passed through a series of intracellular biochemical reactions, in which phosphorylation of CheY is controlled. In this way bacteria accomplish chemotactic behavior.
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Escherichia coli is a common kind of engineer bacteria, which is convenient for genetic manipulation. It is likely that we make use of the chemotactic pathway in E.coli, making them detect and move toward a special chemical substance, maybe a certain kind of pollutant. If the genetic engineering strain also has the ability of degrading aimed chemicals, efficiency of pollution treatment can be hopefully improved a lot. However, the natural ligands concerning chemotaxis in E.coli are limited in several kinds of nutrition, such as carbohydrate and amino acids. Strains that can detecting more kinds of organic substances and even heavy metal ions is planed to be got through the reconstruction of chemotaxis system.
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  == Background ==
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  == Design ==
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  == Predicted Result ==
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  == Related literature ==
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[[Modeling]]
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[[Laboratory Work]]
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  == Scheme ==
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  == Lab Log ==
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  == Protocols ==
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  == Molecular cloning ==
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  == Bacteria behavior ==
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[[Devices and Parts
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Parts]]
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  == Protein Coding ==
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  == Regulatory ==
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  == Vectors ==
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  == Others ==
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Devices
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[[Communication]]
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  == Meet up ==
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  == Phone ==
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  == E-mails ==
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[[Doodle Board]]
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    Contact us: sasbthu@yahoo.cn
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Latest revision as of 04:44, 30 October 2008


HOME Team Project 1 Project 2 Parts Modelling Notebook Doodle Board


554.jpg


Contents

Our ideas

Poor Driver In a Strange Car

The car is strange because it can only run forward or tumble. The probability of the two states is controlled through a handle in it. Even worth, there are no windows on this car but a barometer showing local altitude. How should the driver do to reach the top of the hill and stay at there? ... If you think about the design of bacterial chemotaxis pathway, you will find that this pathway just plays the role of the driver in the story above. Interestingly, we find E. coli chemotaxis pathway realizes this delicate dicision-making process through the interactions amount handful molecules. Our project will show how we learn the design principles from native pathway to complete our device.

Introduction of Tsinghua University

<background-color:#ACF8AE; color:#ACF8AE">

Tsinghua University was established in 1911, originally under the name “Tsinghua Xuetang”. The school was renamed "Tsinghua School" in 1912. The university section was founded in 1925. The name “National Tsinghua University” was adopted in 1928.click here to see more pictures

The educational philosophy of Tsinghua is to "train students with integrity." Among over 120,000 students who have graduated from Tsinghua since its founding are many outstanding scholars, eminent entrepreneurs and great statesmen remembered and respected by their fellow Chinese citizens.

With the motto of “Self-Discipline and Social Commitment” and the spirit of “Actions Speak Louder than Words”, Tsinghua University is dedicated to the well-being of Chinese society and to world development.

Thu 1.jpg

News

 Jamboree is coming in  8 days!
 Tsinghua team, Beijing_Normal team, USTC team will lodge together during the Jamboree.
  last edit by Ylzouyilong Oct 29.2008


Communication

Communication and Interaction

Acknowledgement

Tsinghua.gifBiobricks.pngSB4.0.gifInvitrogen.jpgMathwork.jpgGeneart.gifDSM3.GIF

HOME Team Project 1 Project 2 Parts Modelling Notebook Doodle Board
06.jpeg
== Headline text ==
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