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| - | {{Freiburg2008_Main|
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| - | Content=
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| - | <div style="font-size:18pt;">
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| - | <font face="Arial Rounded MT Bold" style="color:#010369">_DNA-Origami</font></div>
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| - | <br><br>
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| - | ==Introduction==
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| - | Paul Rothemund has discovered that it is possible to shape M13-Phage single-strand-DNA simply adding oligonucleotides that will work as „brackets“ when complementing the long single-strand.<br> In this way, one can generate for example DNA-squares of a certain size with „nods“ at certain distances.
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| - | One member of our team, Daniel Hautzinger, has recently finished his diploma-thesis on Origami-DNA and the possibilities of generating patterns on these square surfaces by modifying the oligo-nucleotides that build up the nod-points.<br>
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| - | As the antigens NIP and fluoresceine can as well be fused to these oligos, we had found the seemingly perfect tool to present strictly defined two-dimensional antigen-patterns to cells carrying our synthetic receptor system.
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| - | [[Image:Freiburg2008_Fab_on_Origami_animated.gif|800 px]]
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| - | ==Literature==
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| - | *Paul W. K. Rothemund: Nature 440, 297-302 (16 March 2006)
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| - | }}
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Latest revision as of 06:32, 30 October 2008
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