Team:MIT
From 2008.igem.org
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*Read our '''promotional brochure''' to learn about synthetic biology at MIT ([[media:mit_igem2008_brochure_front.gif|front]] and [[media:mit_igem2008_brochure_back.gif|back]]). | *Read our '''promotional brochure''' to learn about synthetic biology at MIT ([[media:mit_igem2008_brochure_front.gif|front]] and [[media:mit_igem2008_brochure_back.gif|back]]). | ||
*iGEM at MIT is possible because of '''outside support''', contact Tom Knight (tk [at] mit.edu) to help out! | *iGEM at MIT is possible because of '''outside support''', contact Tom Knight (tk [at] mit.edu) to help out! | ||
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*<html> | *<html> | ||
<script language="JAVASCRIPT"><!-- update your browser, silly--> | <script language="JAVASCRIPT"><!-- update your browser, silly--> | ||
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display = Math.floor((Jamboree.getTime() - Today.getTime())/msInADay); | display = Math.floor((Jamboree.getTime() - Today.getTime())/msInADay); | ||
document.write("There are " + display +" days left until the Jamboree!"); | document.write("There are " + display +" days left until the Jamboree!"); | ||
- | // </script> | + | // </script> |
</html> | </html> | ||
</div> | </div> |
Revision as of 15:14, 24 June 2008
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* Our goal is to engineer a common yogurt bacteria, Lactobacillus bulgaricus, so that it will express the 20aa peptide p1025. A clinical study (Kelly CG et al.; Nature Biotechnol. 1999) reports that p1025 is good for your teeth. p1025 reduces oral colonization of Streptococcus mutans, a tooth-decaying bacterium. * o Stage 1: Construction of p1025 fusion peptide and expression of gene in E. coli. This is an intermediate step to evaluate gene function and protein secretion/efficacy. o Stage 2: Binding Assay - see if the p1025 produced by E.coli inhibits binding of S. mutants to hydroxyapatite (HA) beads. o Stage 3: Expression of p1025 in Lactobacillus. o Stage 4: Make yogurt with modified Lactobacillus and test for inhibition of S. mutants binding.
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