Team:NYMU-Taipei

From 2008.igem.org

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<dt>Banner</dt>
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<span><img src="/wiki/images/9/93/NYMU_Bannerinpic_700px.png" width="700" alt="BacToKidney - Toward a better quality of life"></span>
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<dt>pH Sensor</dt>
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<span><div class="first">pH Sensor</div>
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<div class="rest">A sensor of proton concentration (pH). Activates in a high pH environment.</div></span>
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<div class="rest">Attachment to the small intestine.</div></span>
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<dt>Urea</dt>
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<span><div class="first">Clearance of Urea</div>
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<div class="rest">A Urea clearance device.</div></span>
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<div class="rest">The device managing the clearance of guanidino compounds.</div></span>
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<dt>Phosphate</dt>
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<dd id="p"><a href="./Team:NYMU-Taipei/Project/Phosphate" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
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<span><div class="first">Clearance of Phosphate</div>
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<div class="rest">A Phosphate clearance and balance device.</div></span>
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</a></dd>
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<div id="cartoonmap" style="text-align:left;">
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<dt>Time Regulation</dt>
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<span id="bactokidney">BacToKidney!<br>
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<dd id="time"><a href="./Team:NYMU-Taipei/Project/Time_Regulation" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
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Move your mouse on the image below to navigate.
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<span><div class="first">Time Regulation</div>
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</span>
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<div class="rest">Using oscillators to measure time, it enables detachment from the small intestine after a certain amount of time.</div></span>
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<div class="info">
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</a></dd>
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<div id="sensor"><a id="asensor" href="./Team:NYMU-Taipei/Project/pH_Sensor" title="pH Sensor">
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</dl>
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<span class="n">1.</span>
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<span class="descr">pH Sensor
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<br>A sensor of pH's.
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</span>
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</a></div>
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<div id="attachment"><a id="aattachment" href="./Team:NYMU-Taipei/Project/Attachment" title="Attachment">
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<span class="n">2.</span>
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<span class="descr">Attachment
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<br>Attachment to the small intestine.
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</span>
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</a></div>
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<div id="urea"><a id="aurea" href="./Team:NYMU-Taipei/Project/Urea" title="Urea">
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<span class="n">3a.</span>
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<span class="descr">Urea
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<br>Clearance of Urea.
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</span>
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</a></div>
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<div id="phosphate"><a id="aphosphate" href="./Team:NYMU-Taipei/Project/Phosphate" title="Phosphate">
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<span class="n">3b.</span>
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<span class="descr">Phosphate
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<br>Clearance of Phosphate.
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</span>
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</a></div>
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<div id="guanidine"><a id="aguanidine" href="./Team:NYMU-Taipei/Project/Guanidine" title="Guanidine">
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<span class="n">3c.</span>
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<span class="descr">Guanidine
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<br>Clearance of Guanidine.
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</span>
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</a></div>
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<div id="timeregulation"><a id="atimeregulation" href="./Team:NYMU-Taipei/Project/Time_Regulation" title="Time Regulation">
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<span class="n">4.</span>
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<span class="descr">Time Regulation
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<br>Detachment after a specified period of time.
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</span>
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</a></div>
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</div>
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{{:Team:NYMU-Taipei/Links}}
{{:Team:NYMU-Taipei/Links}}
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{| style="width:700px;border:1px solid gray;"
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{| style="width:965px;border:1px solid gray;"
|-
|-
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| style="vertical-align:top;width:50%;border-right:1px solid gray;" |  <font size="4"><b>'''BacToKidney'''</b></font> - ''Hope through Research''.
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| style="vertical-align:top;width:50%;border-right:1px solid gray;" |  <font size="4"><b>'''BacToKidney'''</b></font> - ''Toward a better quality of life''.
<br>'''Goal:'''
<br>'''Goal:'''
*Use designer bacteria to replace a hemodialysis machine to remove (filter out) toxic waste for treating kidney failure.
*Use designer bacteria to replace a hemodialysis machine to remove (filter out) toxic waste for treating kidney failure.
Line 241: Line 202:
* The mortality rate of patients undergoing maintenance hemodialysis remains unacceptably high.
* The mortality rate of patients undergoing maintenance hemodialysis remains unacceptably high.
* An extremely high morbidity and a relatively low quality of life (due in part to a high level of dependence and unemployment) and high cost have also been observed.
* An extremely high morbidity and a relatively low quality of life (due in part to a high level of dependence and unemployment) and high cost have also been observed.
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<br>'''How our project is divided:'''
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<br>'''Our Design:'''
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* [[/Project/pH Sensor | pH Sensor]]
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* After ingesting our BacToKidney capsule, it passes the through stomach without taking any action, nor being digested, and proceeds to the small intestine. Once in the small intestine, the [[Team:NYMU-Taipei/Project/pH Sensor|pH Sensor]] detects the change in pH and activates the clearance processes of [[Team:NYMU-Taipei/Project/Urea|Urea]], [[Team:NYMU-Taipei/Project/Phosphate|Phosphate]], and [[Team:NYMU-Taipei/Project/Guanidine|Guanidine]] from the body. To allow itself more time to perform its tasks, the [[Team:NYMU-Taipei/Project/pH Sensor|pH Sensor]] also activates the [[Team:NYMU-Taipei/Project/Attachment|Attachment]] process, making the capsule attach itself to the small intestine. After a pre-selected amount of time has passed (controlled by the [[Team:NYMU-Taipei/Project/Time Regulation|time regulating oscillators]]), the capsule detaches itself from the small intestine and exits the body.
 +
<br>'''The parts our project is made up of:'''
 +
* [[Team:NYMU-Taipei/Project/pH Sensor | pH Sensor]]
** A sensor of '''proton concentration (pH)'''
** A sensor of '''proton concentration (pH)'''
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* [[/Project/Attachment | Attachment]]
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* [[Team:NYMU-Taipei/Project/Attachment | Attachment]]
** An '''Attachment anchor''' that attaches to the small intestine
** An '''Attachment anchor''' that attaches to the small intestine
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* [[/Project/Urea | Clearance of Urea]]
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* [[Team:NYMU-Taipei/Project/Urea | Clearance of Urea]]
** A '''Urea''' clearance device  
** A '''Urea''' clearance device  
-
* [[/Project/Phosphate | Clearance of Phosphate]]
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* [[Team:NYMU-Taipei/Project/Phosphate | Clearance of Phosphate]]
** A '''Phosphate''' clearance and balance device
** A '''Phosphate''' clearance and balance device
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* [[/Project/Guanidine | Clearance of Guanidine]]
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* [[Team:NYMU-Taipei/Project/Guanidine | Clearance of Guanidine]]
** A '''Guanidine''' clearance device
** A '''Guanidine''' clearance device
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* [[/Project/Time Regulation | Time Regulation]]
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* [[Team:NYMU-Taipei/Project/Time Regulation | Time Regulation]]
** Enables detachment from the small intestine after a certain amount of time
** Enables detachment from the small intestine after a certain amount of time
** Experimenting with two systems:
** Experimenting with two systems:
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*** [[/Project/Time_Regulation/Cyanoxilator|Cyanoxilator]]: A tuneable cyanobacterial natural (sinusoidal) oscillator implemented in ''E. coli''.
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*** [[Team:NYMU-Taipei/Project/Time_Regulation/Cyanoxilator|Cyanoxilator]]: A tuneable cyanobacterial natural (sinusoidal) oscillator implemented in ''E. coli''.
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*** [[/Project/Time_Regulation/Reloxilator|Reloxilator]]: A tuneable intracell-synchronized relaxation oscillator.
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*** [[Team:NYMU-Taipei/Project/Time_Regulation/Reloxilator|Reloxilator]]: A tuneable intracell-synchronized relaxation oscillator.
| style="vertical-align:top;" | {{:Team:NYMU-Taipei/News}} <!-- Edit the News page for news please. -->
| style="vertical-align:top;" | {{:Team:NYMU-Taipei/News}} <!-- Edit the News page for news please. -->
|}
|}
 +
{{:Team:NYMU-Taipei/Footer}}

Latest revision as of 02:41, 29 October 2008


Banner
pH Sensor
pH Sensor
A sensor of proton concentration (pH). Activates in a high pH environment.
Attachment
Attachment
Attachment to the small intestine.
Urea
Clearance of Urea
A Urea clearance device.
Guanidine
Clearance of Guanidine
The device managing the clearance of guanidino compounds.
Phosphate
Clearance of Phosphate
A Phosphate clearance and balance device.
Time Regulation
Time Regulation
Using oscillators to measure time, it enables detachment from the small intestine after a certain amount of time.



BacToKidney - Toward a better quality of life.


Goal:

  • Use designer bacteria to replace a hemodialysis machine to remove (filter out) toxic waste for treating kidney failure.


Why is it an interesting problem?

  • Approximately 1.3 million people globally have chronic kidney failure that requires either renal transplantation or dialysis - for such patients, the established treatment is hemodialysis
  • The mortality rate of patients undergoing maintenance hemodialysis remains unacceptably high.
  • An extremely high morbidity and a relatively low quality of life (due in part to a high level of dependence and unemployment) and high cost have also been observed.


Our Design:

  • After ingesting our BacToKidney capsule, it passes the through stomach without taking any action, nor being digested, and proceeds to the small intestine. Once in the small intestine, the pH Sensor detects the change in pH and activates the clearance processes of Urea, Phosphate, and Guanidine from the body. To allow itself more time to perform its tasks, the pH Sensor also activates the Attachment process, making the capsule attach itself to the small intestine. After a pre-selected amount of time has passed (controlled by the time regulating oscillators), the capsule detaches itself from the small intestine and exits the body.


The parts our project is made up of:

News and Updates.
  • 2008-10-28: Gradually migrating the wiki pages to here.
  • 2008-08-12: The team page now displays us.
  • 2008-08-06: New Wikipage design put up!
  • 2008-08-01: Wikipage Online!

Retrieved from "http://2008.igem.org/Team:NYMU-Taipei"