Team:BrownTwo

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Latest revision as of 00:42, 30 October 2008

A Genetic Limiter Circuit in S. cerevisiae

We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold. The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity. Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.

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-<!-- *** What falls between these lines is the Alert Box!  You can remove it from your pages once you have read and understood the alert *** -->
+{{limitertemp}}
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+==A Genetic Limiter Circuit in ''S. cerevisiae''==
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-This is a template page. READ THESE INSTRUCTIONS.
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-<div id="instructions" style="text-align: center; font-weight: normal; font-size: small; color: #f6f6f6; padding: 5px;">
-You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
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+[[image:Glyph.png|center|400px]]
+<br><p>
+We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold.  The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity.  Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.
+</p>
-{|align="justify"
+<center>'''''This page is best viewed with any browser but Internet Explorer.'''''
-|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
+</center>
-|[[Image:Example_logo.png|200px|right|frame]]
-|-
-|
-''Tell us more about your project.  Give us background.  Use this is the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
-|[[Image:Team.png|right|frame|Your team picture]]
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-|align="center"|[[Team:BrownTwo | Team Example 2]]
-|}
-<!--- The Mission, Experiments --->
-{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
-!align="center"|[[Team:BrownTwo|Home]]
-!align="center"|[[Team:BrownTwo/Team|The Team]]
-!align="center"|[[Team:BrownTwo/Project|The Project]]
-!align="center"|[[Team:BrownTwo/Parts|Parts Submitted to the Registry]]
-!align="center"|[[Team:BrownTwo/Modeling|Modeling]]
-!align="center"|[[Team:BrownTwo/Notebook|Notebook]]
-|}
-(''Or you can choose different headings.  But you must have a team page, a project page, and a notebook page.'')