Team:UCSF

From 2008.igem.org

(Difference between revisions)
 
(64 intermediate revisions not shown)
Line 1: Line 1:
-
<!-- *** What falls between these lines is the Alert Box!  You can remove it from your pages once you have read and understood the alert *** -->
+
<html xmlns="http://www.w3.org/1999/xhtml">
-
 
+
<head>
-
<html>
+
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8" />
-
<div id="box" style="width: 700px; margin-left: 137px; padding: 5px; border: 3px solid #000; background-color: #fe2b33;">
+
<title>Untitled Document</title>
-
<div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
+
<style type="text/css">
-
This is a template page. READ THESE INSTRUCTIONS.
+
<!--
-
</div>
+
body {
-
<div id="instructions" style="text-align: center; font-weight: normal; font-size: small; color: #f6f6f6; padding: 5px;">
+
margin-left: 20px;
-
You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
+
margin-right: 20px;
-
</div>
+
width: 900px;
-
<div id="warning" style="text-align: center; font-weight: bold; font-size: small; color: #f6f6f6; padding: 5px;">
+
}
-
You <strong>MUST</strong> have a team description page, a project abstract, a complete project description, and a lab notebook. PLEASE keep all of your pages within your Team:Example namespace.
+
.style2 {
-
</div>
+
font-size: 30px;
-
</div>
+
font-weight: bold;
 +
}
 +
-->
 +
</style></head>
 +
<body>
 +
<p align="center"><img src="https://static.igem.org/mediawiki/2008/0/0e/UCSF2008logo2.jpg" width="276" height="288" align="middle" /></p>
 +
<p  align="center" class="style2">CHROMATIN MEMORIES<br></br>A new tool for Synthetic Biology</p>
 +
<blockquote>
 +
  <br>
 +
  <br>
 +
  <br>
 +
      <h2 align="left">Epigenetic control of gene expression</h2>
 +
      <p align="left">The cells of higher eukaryotes utilize chromatin state to encode &quot;permanent&quot; epigenetic changes in gene expression.  For example, signals received by a cell during the course of development can induce the partitioning of the genome into accessible (euchromatin) and inaccessible (heterochromatin) regions that specify the fate of that cell.  This epigenetic profile, in which blocks of gene are &quot;silenced&quot; by heterochromatin, is stably maintained and inherited by daughter cells.  Thus, chromatin state provides a higher level of gene expression control that is regional (acting on many genes at once), dominant over transcription factors, ultra-cooperative (all or none), and highly stable (memory).  Engineerable control over chromatin state would clearly be a powerful tool for Synthetic Biology.  </p>
 +
      <p align="left"><strong>We have constructed and characterized a synthetic silencing system in <em>S. cerevisiae</em> in which we can inducibly silence specific loci in the genome. </strong></p>
 +
      <p align="left">This foundational technology will facilitate the construction of complex genetic circuits with memory, and has potential application in the engineering of cell differentiation in higher eukaryotes.</p>
 +
    <p align="right"><a href="https://2008.igem.org/Team:UCSF/Project">More...</a></p>
 +
      <p align="right">&nbsp;</p>
 +
      <table width="870" border="0" cellpadding="3">
 +
        <tr>
 +
          <td width="202" height="208"><img src="https://static.igem.org/mediawiki/2008/b/b6/Our_project.jpg" alt="" width="200" height="201" /></td>
 +
          <td width="650"><h3>&nbsp;</h3>
 +
            <blockquote>
 +
              <h3>OUR PROJECT</h3>
 +
              <blockquote>
 +
                <h4><a href="https://2008.igem.org/Team:UCSF/Project">Synthetic Chromatin Bit</a></h4>
 +
                <ul>
 +
                  <ul>
 +
                    <li><a href="https://2008.igem.org/Team:UCSF/Synthetic Chromatin Design">Design</a></li>
 +
                    <li><a href="https://2008.igem.org/Team:UCSF/Synthetic Chromatin Properties">Properties</a></li>
 +
                    <li><a href="https://2008.igem.org/Team:UCSF/Modeling">Modeling</a></li>
 +
                    <li><a href="https://2008.igem.org/Team:UCSF/Strengthening Silencing">Strengthening Silencing</a></li>
 +
                    <li><a href="https://2008.igem.org/Team:UCSF/Higher_order_systems">Higher-Order Systems</a></li>
 +
                    <li><a href="https://2008.igem.org/Team:UCSF/Materials and Methods">Materials and Methods</a></li>
 +
                  </ul>
 +
                </ul>
 +
                <h4><a href="https://2008.igem.org/FAQs_about_our_Project">FAQs about our Project</a></h4>
 +
                <h4><a href="https://2008.igem.org/Team:UCSF/Human Practices">Human Practices</a></h4>
 +
              </blockquote>
 +
            </blockquote>
 +
          <p>&nbsp;</p></td>
 +
        </tr>
 +
      </table>
 +
      <table width="870" border="0" cellpadding="3">
 +
        <tr>
 +
          <td width="202" height="208"><img src="https://static.igem.org/mediawiki/2008/f/f5/Our_team.jpg" alt="" width="200" height="200" /></td>
 +
          <td width="650"><h3>&nbsp;</h3>
 +
              <blockquote>
 +
                <h3>OUR TEAM</h3>
 +
                <blockquote>
 +
                  <h4><a href="https://2008.igem.org/Team:UCSF/Team">Team Members</a></h4>
 +
                  <h4><a href="https://2008.igem.org/Team:UCSF/Summer Experience">Summer Experience</a></h4>
 +
                  <h4><a href="https://2008.igem.org/Team:UCSF/Notebook">Notebooks</a></h4>
 +
                  <h4><a href="https://2008.igem.org/Everything_you_ever_wanted_to_know_about_AarI">Aar1 Cloning System</a></h4>
 +
                  <h4><a href="https://2008.igem.org/Team:UCSF/Parts">Parts submitted to the Registry</a></h4>
 +
                  <h4><a href="https://2008.igem.org/FAQs_about_our_Team">FAQs about our Team</a></h4>
 +
                </blockquote>
 +
              </blockquote>
 +
          <p>&nbsp;</p></td>
 +
        </tr>
 +
      </table>
 +
<br><br></br></br>
 +
  </blockquote>
 +
</body>
</html>
</html>
-
<!-- *** End of the alert box *** -->
 
 +
'''UCSF iGEM 2008 is sponsored by...'''
-
{|align="justify"
 
-
Our team is composed of 6 high-school students - Cathy, Jacinto, Leeza, Ryan, Tiffany and Willis,- and 3 undergrads - Alex, Andrej and Jimmy.
 
-
|[[Image:Example_logo.png|200px|right|frame]]
 
-
|-
 
-
|
 
-
''Tell us more about your project.  Give us background.  Use this is the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
 
-
|[[Image:Team.png|right|frame|Your team picture]]
 
-
|-
 
-
|
 
-
|align="center"|[[Team:UCSF | Team Example 2]]
 
-
|}
 
-
<!--- The Mission, Experiments --->
+
<html>
-
 
+
<p align="center"><img src="https://static.igem.org/mediawiki/2008/1/16/Sponsors.png" width="650" height="129" align="middle" /></p></html>
-
{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
+
-
!align="center"|[[Team:UCSF|Home]]
+
-
!align="center"|[[Team:UCSF/Team|The Team]]
+
-
!align="center"|[[Team:UCSF/Project|The Project]]
+
-
!align="center"|[[Team:UCSF/Parts|Parts Submitted to the Registry]]
+
-
!align="center"|[[Team:UCSF/Modeling|Modeling]]
+
-
!align="center"|[[Team:UCSF/Notebook|Notebook]]
+
-
|}
+
-
(''Or you can choose different headings.  But you must have a team page, a project page, and a notebook page.'')
+

Latest revision as of 03:11, 30 October 2008

Untitled Document

CHROMATIN MEMORIES

A new tool for Synthetic Biology




Epigenetic control of gene expression

The cells of higher eukaryotes utilize chromatin state to encode "permanent" epigenetic changes in gene expression. For example, signals received by a cell during the course of development can induce the partitioning of the genome into accessible (euchromatin) and inaccessible (heterochromatin) regions that specify the fate of that cell. This epigenetic profile, in which blocks of gene are "silenced" by heterochromatin, is stably maintained and inherited by daughter cells. Thus, chromatin state provides a higher level of gene expression control that is regional (acting on many genes at once), dominant over transcription factors, ultra-cooperative (all or none), and highly stable (memory). Engineerable control over chromatin state would clearly be a powerful tool for Synthetic Biology.

We have constructed and characterized a synthetic silencing system in S. cerevisiae in which we can inducibly silence specific loci in the genome.

This foundational technology will facilitate the construction of complex genetic circuits with memory, and has potential application in the engineering of cell differentiation in higher eukaryotes.

More...

 

 

OUR PROJECT

Synthetic Chromatin Bit

FAQs about our Project

Human Practices

 

 

OUR TEAM

Team Members

Summer Experience

Notebooks

Aar1 Cloning System

Parts submitted to the Registry

FAQs about our Team

 





UCSF iGEM 2008 is sponsored by...


Retrieved from "http://2008.igem.org/Team:UCSF"