Team:BrownTwo/Project

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=A Genetic Limiter Circuit in ''S. cerevisiae''=
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{| style="color:#CC0000;background-color:#FFFFFF;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="70%" align="center"
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This is a template page. READ THESE INSTRUCTIONS.
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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
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You <strong>MUST</strong> have a team description page, a project abstract, a complete project description, and a lab notebook.  PLEASE keep all of your pages within your Team:Example namespace. 
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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
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|align="center"|[[Team:BrownTwo | Team Example 2]]
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{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
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!align="center"|[[Team:BrownTwo|Home]]
!align="center"|[[Team:BrownTwo|Home]]
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!align="center"|[[Team:BrownTwo/Team|The Team]]
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!align="center"|[[Team:BrownTwo/Team|The Duo]]
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!align="center"|[[Team:BrownTwo/Project|The Project]]
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!align="center"|[[Team:BrownTwo/Project|The Concept]]
!align="center"|[[Team:BrownTwo/Parts|Parts Submitted to the Registry]]
!align="center"|[[Team:BrownTwo/Parts|Parts Submitted to the Registry]]
!align="center"|[[Team:BrownTwo/Modeling|Modeling]]
!align="center"|[[Team:BrownTwo/Modeling|Modeling]]
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!align="center"|[[Team:BrownTwo/Notebook|Notebook]]
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!align="center"|[[Team:BrownTwo/Notebook|Protocols]]
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!align="center"|[[Team:BrownTwo/Modeling|Modeling]]
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(''Or you can choose different headings.  But you must have a team page, a project page, and a notebook page.'')
 
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== '''Overall project''' ==
 
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Your abstract
 
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== '''Project Overview''' ==
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Numerous disease states in multicellular organisms involve anomalous expression patterns of endogenous genes.  Tumor growth, associated with the overexpression of oncogenes, is one vexing example in which this occurs.  While extremes of gene expression can damage living systems, normal expression is necessary for healthy function.  We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold.  The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity.  Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.
== Project Details==
== Project Details==

Latest revision as of 04:23, 27 October 2008

Brown logo.jpg



Contents

A Genetic Limiter Circuit in S. cerevisiae

Home The Duo The Concept Parts Submitted to the Registry Modeling Protocols Modeling



Project Overview

Numerous disease states in multicellular organisms involve anomalous expression patterns of endogenous genes. Tumor growth, associated with the overexpression of oncogenes, is one vexing example in which this occurs. While extremes of gene expression can damage living systems, normal expression is necessary for healthy function. We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold. The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity. Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.

Project Details

Part 2

The Experiments

Part 3

Results

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