Team:Alberta NINT

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            <td width="599" height = "200"></br>NINT iGEM <strong></br></br>
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            Logi - col[i]</strong><span class="style6"></br></br>
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            <br />
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            A gateway to things both logical and colilogical,  coli-licious, coli-ish, coli-ly, small living  stuff. </span><br /></td>
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            <td width="251"><img src="https://static.igem.org/mediawiki/2008/e/e3/NINTiGEM_Logicoli.jpg" width="251" height="180" /></td>
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      <td width="103"><div align="center" class="style5"><a href="https://2008.igem.org/Team:Alberta_NINT">HOME</a> </div></td>
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      <td width="91"><div align="center" class="style1"><a href="https://2008.igem.org/Team:Alberta_NINT/Team" class="style1">The Team </a></div></td>
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      <td width="114"><div align="center" class="style1"><a href="https://2008.igem.org/Team:Alberta_NINT/Project" class="style1">The Project </a></div></td>
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      <td width="145"><div align="center" class="style1"><a href="https://2008.igem.org/Team:Alberta_NINT/Protocols" class="style1">Lab Protocols</a></div></td>
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      <td width="133"><div align="center" class="style1"><a href="https://2008.igem.org/Team:Alberta_NINT/Parts" class="style1">Bits And Pieces </a></div></td>
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      <td width="111"><div align="center" class="style1"><a href="https://2008.igem.org/Team:Alberta_NINT/Modeling" class="style1">Modeling</a></div></td>
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      <td width="143"><div align="center" class="style1"><a href="https://2008.igem.org/Team:Alberta_NINT/Notebook" class="style1">Notebook</a></div></td>
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                <td width="598" bgcolor="#990000" align="left"><span class="style7">Project Summary</span></td>
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<p style ="padding: 20px; text-align: justify">
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Two major hurdles facing the development of complex genetic logic circuits are device connectibility and device extensibility.  Connectibility refers to the ability to connect the output of one device to the input of another device, while extensibility refers to the dual abilities to rationally design new devices and to combine multiple devices in one organism.  Our project uses terminator/attenuator (T/A) hairpin sequences (gates) to control transcription and anti-sense RNA as input/output signals to/from the devices.  We call this approach Terminator/Attenuator anti-sense Logic (T/AasL – pronounced “tossle”).  It solves the connectibility problems of common protein-based approaches because the anti-sense output of one device is used to disrupt formation of T/A hairpin structures of downstream devices, thus activating them.  In addition, because RNA secondary structures can be rationally designed (using our m-fold derived analysis program) we can readily construct a large family of devices with minimal cross-talk for inclusion in a single cell.  </p>
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                <td bgcolor="#990000"><span class="style8">Sponsors</span></td>
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                    <li class="style9">Alberta Ingenuity </li>
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                  <li class="style9">Department of Medical Microbiology and Immunology (University of Alberta) </li>
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                  <li class="style9">Department of Cell Biology (University of Alberta) </li>
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                  <li class="style9">National Institute for Nanotechnology </li>
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Latest revision as of 20:31, 28 March 2016

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