Team:Rice University

From 2008.igem.org

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[[Team:Rice_University/OUR TEAM|OUR TEAM]] ::: [[Team:Rice_University|SUMMARY]] :::  [[Team:Rice_University/BACKGROUND|BACKGROUND]] ::: 
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[[Team:Rice_University/STRATEGY|STRATEGY]] ::: [[Team:Rice_University/CONSTRUCTS|CONSTRUCTS]] :::  [[Team:Rice_University/RESULTS|RESULTS]] :::  [[Team:Rice_University/CONCLUSIONS|ONGOING WORK]]
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Resveratrol, a phytochemical in plants, has been implicated as a natural product that extends lifespan and prevents cancer, coronary disease and neurodegenerative maladies. Unfortunately, resveratrol is only present at appreciable levels in a small number of foods, such as red wine, peanuts, and blueberries. To create an alternative source for resveratrol consumption, we are introducing a biosynthetic pathway for this compound into a brewing strain of yeast and examining whether this strain can be engineered to produce resveratrol during beer fermentation. Given the high worldwide consumption of beer and the low cost of production, unfiltered beer brewed using our genetically modified yeast should provide a cost-effective source of pharmacologically-active resveratrol. This engineering approach should be useful for cheap biosynthesis of other oxygen-sensitive prophylactics.
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'''    Welcome to Rice University's 2008 iGEM wiki page. We have two new projects this year! <BR>
 
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Our primary project is BIOBEER, where we are genetically engineering the biosynthetic pathway for resveratrol production into a brewing yeast strain. Resveratrol has been shown to have a plethora of health benefits, including anti-cancer and anti-viral activity, cardio- and neuro-protective effects, modulation of diabetes, and anti-aging effects. Although research has been done previously to produce resveratrol in various organisms, no one to date has developed a yeast strain able to synthesize resveratrol in a de novo manner. We are going one step further, characterizing resveratrol production during anaerobic fermentation with the intent of creating a beer that contains all the health benefits of wine. Get ready for resveratrol in a fizzy ready-to-consume beverage!
 
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Our second project looks at the potential of using phage as a signal amplification system. When a bacterial population is infected by bacteriophage, there is an exponential increase in the number of phage particles produced. By designing phage in which the replication of the phage is coupled to some environmental stimulus, such as the presence of another bacterium, we can produce an extremely sensitive biodetector.'''
 
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(More detailed descriptions of projects to be added.)
 
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== '''BioBeer: Producing Resveratrol During Fermentation in Beer''' ==
 
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[[Image:iGEM-2008-Splash.jpg]]
 
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Stuff about Beer HERE
 
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== '''Phage Signal Amplifier Project''' ==
 
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!align="center"|[[Team:Rice_University|Home]]
 
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!align="center"|[[Team:Rice_University/Team|The Team]]
 
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!align="center"|[[Team:Rice_University/Project|The Project]]
 
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!align="center"|[[Team:Rice_University/Parts|Parts Submitted to the Registry]]
 
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!align="center"|[[Team:Rice_University/Modeling|Modeling]]
 
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!align="center"|[[Team:Rice_University/Notebook|Notebook]]
 
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Latest revision as of 22:36, 8 January 2009


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OUR TEAM ::: SUMMARY ::: BACKGROUND ::: STRATEGY ::: CONSTRUCTS ::: RESULTS ::: ONGOING WORK

Resveratrol, a phytochemical in plants, has been implicated as a natural product that extends lifespan and prevents cancer, coronary disease and neurodegenerative maladies. Unfortunately, resveratrol is only present at appreciable levels in a small number of foods, such as red wine, peanuts, and blueberries. To create an alternative source for resveratrol consumption, we are introducing a biosynthetic pathway for this compound into a brewing strain of yeast and examining whether this strain can be engineered to produce resveratrol during beer fermentation. Given the high worldwide consumption of beer and the low cost of production, unfiltered beer brewed using our genetically modified yeast should provide a cost-effective source of pharmacologically-active resveratrol. This engineering approach should be useful for cheap biosynthesis of other oxygen-sensitive prophylactics.


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