Team:Michigan

From 2008.igem.org

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{{Michigan Header}}
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<div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
 
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This is a template page. READ THESE INSTRUCTIONS.
 
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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
 
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You <strong>MUST</strong> have a team description page, a project abstract, a complete project description, and a lab notebook.  PLEASE keep all of your pages within your Team:Example namespace. 
 
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{|class="wikitable" border="0" cellpadding="10" cellspacing="1" style="padding: 1px; background-color:dodgerblue;  border: 1px solid mediumblue; text-align:center"
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!width="20%" align="left" valign="top" style="background:gold; color:black"|
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= '''<font color=royalblue size=6>''Beauty''... and the CLOCK</font>''' =
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==<B><font size=4>Circadian Clocking... in E. Coli!</font></B>==
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The human body's "clock" regulates the daily cycles of many physiological and metabolic processes, such as the sleep/wake cycle and feeding rhythms. It is controlled by the interplay of numerous molecular factors that orchestrate complex feedback loops and processes that are fundamentally mediated by gene expression and the events that follow it. We are working on constructing a synthetic clock, affectionately deemed "The Sequestillator," that is analogous to the mammalian clock. Our clock consists of two parts: an activator with constitutive expression and a promoter that drives the production of a repressor that binds and "sequesters" the activator away from the promoter. While intuitively it seems that this system may reach a steady state rather than oscillate, simulations have shown that under certain rapid equilibrium and tight binding conditions, this circuit does exhibit oscillations. We are currently involved in building and testing of this device.</div><br>
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==<B><font size=4>Sequestillator Topology</font></B>==
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<div align=center>[[Image:New full topology - gold 2 new.png|500px]]</div>
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[[Image:Clock only - no bg small with m.png]]
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{|align="justify"
 
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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
 
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''Tell us more about your project.  Give us background.  Use this is the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
 
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|[[Image:Team.png|right|frame|Your team picture]]
 
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|align="center"|[[Team:Michigan | Team Example 2]]
 
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<!--- The Mission, Experiments --->
 
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{|class="wikitable" border="0" cellpadding="10" cellspacing="1" style="padding: 1px; background-color:dodgerblue;  border: 1px solid mediumblue; text-align:center"
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!align="center"|[[Team:Michigan|Home]]
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!align="center"|[[Team:Michigan/Team|The Team]]
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!align="center"|[[Team:Michigan/Project|The Project]]
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!align="center"|[[Team:Michigan/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Michigan/Modeling|Modeling]]
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More information about our team and previous iGEM projects can be found on our team wiki: <a href="http://synthbio.engin.umich.edu/wiki/index.php/Main_Page">HERE</a>.
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!align="center"|[[Team:Michigan/Notebook|Notebook]]
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(''Or you can choose different headings.  But you must have a team page, a project page, and a notebook page.'')
 

Latest revision as of 23:12, 29 October 2008


Michigan iGEM website header.jpg

HOME THE TEAM THE PROJECT REGISTRY PARTS NOTEBOOK


Beauty... and the CLOCK

Circadian Clocking... in E. Coli!

The human body's "clock" regulates the daily cycles of many physiological and metabolic processes, such as the sleep/wake cycle and feeding rhythms. It is controlled by the interplay of numerous molecular factors that orchestrate complex feedback loops and processes that are fundamentally mediated by gene expression and the events that follow it. We are working on constructing a synthetic clock, affectionately deemed "The Sequestillator," that is analogous to the mammalian clock. Our clock consists of two parts: an activator with constitutive expression and a promoter that drives the production of a repressor that binds and "sequesters" the activator away from the promoter. While intuitively it seems that this system may reach a steady state rather than oscillate, simulations have shown that under certain rapid equilibrium and tight binding conditions, this circuit does exhibit oscillations. We are currently involved in building and testing of this device.

Sequestillator Topology

New full topology - gold 2 new.png

Clock only - no bg small with m.png


More information about our team and previous iGEM projects can be found on our team wiki: HERE.