Team:Illinois/Project

From 2008.igem.org

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    <td align="center" ><a class="mainLinks" href="https://2008.igem.org/Team:Illinois/Project" >Projects</a> </td>
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!align="center"|[[Team:Illinois/Parts|Parts Submitted to the Registry]]
!align="center"|[[Team:Illinois/Parts|Parts Submitted to the Registry]]
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    <td align="center" ><a class="mainLinks" href="https://2008.igem.org/Team:Illinois" >Home</a> </td>
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    <td align="center" ><a class="mainLinks" href="https://2008.igem.org/Team:Illinois/Project" >Projects</a> </td>
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    <td align="center" ><a class="mainLinks" href="https://2008.igem.org/Team:Illinois/Notebook" >Notebook</a> </td>
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Revision as of 05:33, 8 August 2008

Home Projects Research Articles Protocols Pictures Parts



We are the inaugural iGEM team here at the University of Illinois. We are very excited to be participating and look forward to a summer full of fun, learning, and hopefully a successful project.
Example.png

Contents

Overall project

For our project we intend to create a yeast-based biosensor capable of detecting and signalling the presense of a pathogen. We intend to use directed evolution to develop a cell surface receptor capable of binding the pathogen. This receptor will then initiate a signaling cascade which will induce a change in the yeast, a color change for example. This project is important because there is a demonstrated need for cheap and effective monitoring of water-borne pathogens in the third world where traditional detection methods are not feasible.


Subprojects

To improve our odds of achieving our project we have decided to modulate our team into 3 disparate groups, each pursuing variant methods to accomplish the above goal, that is, cheap detection of water-bourne pathogens. The three methods and teams are detailed below.

If you were not present at the June 10th meeting, pick a group and contact the members.

Antibody GPCR Fusion

This team will attempt pathogen detection by fusing the appropriate antibody domain to a GPCR receptor and upon binding of the target protein (i.e. cholera toxin), linking the resulting signal cascade to transcription of a reporter, GFP or LacZ.

Antibody Receptor Tyrosine Kinase Fusion

This project will attempt to detect a pathogen by using a secreted antibody or antibody fusion protein.

Bimolecular Fluorescence Biosensor

A soluble biosensor that activates a fluorescent protein upon binding a specific biomolecule

Results

Home The Team Notebook Research Articles Protocols The Project Pictures Parts Submitted to the Registry

Home Projects Notebook Research Articles Protocols Pictures Parts

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