Team:University of Sheffield /Project
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<font size="7" color="#151B8D" face="TUOS Stephenson"><'''Overall project'''> | <font size="7" color="#151B8D" face="TUOS Stephenson"><'''Overall project'''> | ||
- | <font size=" | + | <font size="5" color="#151B8D" face="TUOS Blake"><u>'''Project Overview'''</u> |
- | The aim is to engineer a biological machine that will sense microbial contamination of drinking water using quorum sensing, namely, '''''Vibrio cholerae''''', the bacterial species that causes epidemics of cholera. Quorum sensing systems use sensing proteins in the membrane (<em>[http://en.wikipedia.org/wiki/Histidine_kinase histidine-kinases] in this case</em>) to detect molecules excreted by the bacteria’s own species. After detection in the membrane, a phosphate signal is passed down pathway, causing a DNA regulatory effect. Each quorum-sensing species also has its own corresponding quorum-producing protein. In Vibrio cholerae the sensing protein is CqsS and the quorum-producing protein CqsA. | + | <font size="3" color="#151B8D" face="TUOS Blake">The aim is to engineer a biological machine that will sense microbial contamination of drinking water using quorum sensing, namely, '''''Vibrio cholerae''''', the bacterial species that causes epidemics of cholera. Quorum sensing systems use sensing proteins in the membrane (<em>[http://en.wikipedia.org/wiki/Histidine_kinase histidine-kinases] in this case</em>) to detect molecules excreted by the bacteria’s own species. After detection in the membrane, a phosphate signal is passed down pathway, causing a DNA regulatory effect. Each quorum-sensing species also has its own corresponding quorum-producing protein. In Vibrio cholerae the sensing protein is CqsS and the quorum-producing protein CqsA. |
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Revision as of 10:29, 5 September 2008
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