Team:Imperial College

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<center>'''For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.'''<html><br><img width="350px" src="http://i59.photobucket.com/albums/g305/Timpski/Logo1.png"></html></center>
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<center>'''For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.'''<html><br><br><img width="350px" src="http://i59.photobucket.com/albums/g305/Timpski/Logo1.png"></html><br><br></center>
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*Light on
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*Motility arrested
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*Biomaterial produced
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*Light off
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*Biomaterial production stopped, movement resumed
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Revision as of 15:32, 15 October 2008
For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.



  • Light on
  • Motility arrested
  • Biomaterial produced
  • Light off
  • Biomaterial production stopped, movement resumed

Overview
  • First by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location using 3D holography.
  • Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein.
  • Finally, when our bacteria are stationary in the correct location, the biomaterial production is triggered. These biomaterials can self-assemble to form a 3D bio-scaffold.


Overview of our planned system
Basic Circuit Diagram


Applications of our Biofabricator range from regenerative tissue engineering to Bio-Couture.


Please continue on to our project pages - you may want to start with our >>> Project Specifications >>>



The Imperial College Team 2008 has received sponsorship from a number of generous companies. We are grateful for their kind support.



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