"
Team:Paris/Network analysis and design/System improvements
From 2008.igem.org
(Difference between revisions)
| Line 46: | Line 46: | ||
*S2: it amounts to replace single interaction by more complex interactions: should create delay | *S2: it amounts to replace single interaction by more complex interactions: should create delay | ||
| + | we analyze both systems for their capacity to generate oscillations. S2 seems more promising. Thus we further analize S2 for its capacity to generate ''synchrionized'' oscillations. | ||
| + | <!-- | ||
We first analyse S4 due to modularity. | We first analyse S4 due to modularity. | ||
| Line 56: | Line 58: | ||
given analysis results we keep S2. | given analysis results we keep S2. | ||
| + | --> | ||
Revision as of 22:03, 25 October 2008
| System Improvements | |||
|---|---|---|---|
| Name | Description | Evaluation | Links |
| Core system | Figure core system | Zero | Liks core system |
| Modular system | Figure modular system | ** | Links Garcia-Ojalvo |
| Resulting system | Figure resulting system | *** | Links resulting |
| Main conclusion: we keep S2 | |||
Core system does not oscillate. How can we enhance it?
We need a 'delay' so we can:
1 add more genes to the circuit
2 use quorum sensing (qs)
we chose quorum sensing that can allowed both 'delay' and population synchonization. two ways to add it:
- S4: Inspired from Garcia-Ojalvo: oscillating repressilator + oscillating qs module = synchronized oscillations
- S2: it amounts to replace single interaction by more complex interactions: should create delay
we analyze both systems for their capacity to generate oscillations. S2 seems more promising. Thus we further analize S2 for its capacity to generate synchrionized oscillations.
