Team:BrownTwo

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Revision as of 09:50, 29 October 2008

A Genetic Limiter Circuit in S. cerevisiae

We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold. The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity. Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.

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 ==A Genetic Limiter Circuit in ''S. cerevisiae''==
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-    We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold.  The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity.  Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.
+We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold.  The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity.  Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.