From 2008.igem.org
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| - | [[Image:Imperial_2008_Bioprinter_Cartoon.png | center | 600px | Overview of our planned system]]
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| - | [[Image:Imperial_2008_Basic_Circuit.png | center | Basic Circuit Diagram]]
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| - | | + | Applications of our Biofabricator range from regenerative tissue engineering to BioCouture. |
| - | Applications of our Biofabricator range from regenerative tissue engineering to Bio-Couture. | + | |
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Revision as of 17:12, 16 October 2008
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For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.
- Light on
- Motility arrested
- Biomaterial produced
- Light off
- Biomaterial production stopped, movement resumed
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| Overview
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- First by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location using 3D holography.
- Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein.
- Finally, when our bacteria are stationary in the correct location, the biomaterial production is triggered. These biomaterials can self-assemble to form a 3D bio-scaffold.
Applications of our Biofabricator range from regenerative tissue engineering to BioCouture.
Please continue on to our project pages - you may want to start with our >>> Project Specifications >>>
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