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Team:Paris/Network analysis and design/System improvements
From 2008.igem.org
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We need a 'delay' so we can: | We need a 'delay' so we can: | ||
| + | |||
1 add more genes to the circuit | 1 add more genes to the circuit | ||
| + | |||
2 use quorum sensing (qs) | 2 use quorum sensing (qs) | ||
we chose quorum sensing that can allowed both 'delay' and population synchonization. | we chose quorum sensing that can allowed both 'delay' and population synchonization. | ||
| - | two ways to add it: | + | two ways to add it: |
| - | + | *S4: Inspired from Garcia-Ojalvo: oscillating repressilator + oscillating qs module = synchronized oscillations | |
| - | + | *S2: it amounts to replace single interaction by more complex interactions: should create delay | |
| - | + | ||
| + | We first analyse S4 due to modularity. | ||
damped oscillating core system + oscillating qs module = damped oscillations. | damped oscillating core system + oscillating qs module = damped oscillations. | ||
Revision as of 21:58, 25 October 2008
| System Improvements | |||
|---|---|---|---|
| Name | Description | Evaluation | Links |
| Core system | Figure core system | Zero | Liks core system |
| Modular system | Figure modular system | ** | Links Garcia-Ojalvo |
| Resulting system | Figure resulting system | *** | Links resulting |
| Main conclusion: we keep S2 | |||
Core system does not oscillate. How can we enhance it?
We need a 'delay' so we can:
1 add more genes to the circuit
2 use quorum sensing (qs)
we chose quorum sensing that can allowed both 'delay' and population synchonization. two ways to add it:
- S4: Inspired from Garcia-Ojalvo: oscillating repressilator + oscillating qs module = synchronized oscillations
- S2: it amounts to replace single interaction by more complex interactions: should create delay
We first analyse S4 due to modularity.
damped oscillating core system + oscillating qs module = damped oscillations.
We continue with S2:
S0 module in S4 gived us insides in parameters analysis for S2.
given analysis results we keep S2.
