Team:Slovenia/Project

From 2008.igem.org

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<!------------------------------- ZACETEK IGEM 2008 STRANI ------------------------------------------------------>
<!------------------------------- ZACETEK IGEM 2008 STRANI ------------------------------------------------------>
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<div align="center"><img src="https://static.igem.org/mediawiki/2008/0/05/IGEM-Slovenia_btn_v2_1.gif" align="center" width="900" height="30" border="0" usemap="#Map" /></div>
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<li><a href="https://2008.igem.org/Team:Slovenia" target="_self" ><img src="https://static.igem.org/mediawiki/2008/b/b7/Home_btn.gif" width="69" height="30" border="0" /></a>
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<a href="https://2008.igem.org/Team:Slovenia/Background" target="_self">Introduction</a>
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<a href="https://2008.igem.org/Team:Slovenia/Background" target="_self">Immune response</a>
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<a href="https://2008.igem.org/Team:Slovenia/Background" target="_self">Modern vaccines</a>
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<a href="https://2008.igem.org/Team:Slovenia/Project" target="_self">The idea</a>
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<a href="https://2008.igem.org/Team:Slovenia/Project" target="_self">TLR 5</a>
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<a href="https://2008.igem.org/Team:Slovenia/Project" target="_self">TLR 3, TLR 4</a>
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<a href="https://2008.igem.org/Team:Slovenia/Project" target="_self">Experiment`s on laboratory mice</a>
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<a href="https://2008.igem.org/Team:Slovenia/Results" target="_self">Engineered flagellin vaccine</a>
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<a href="https://2008.igem.org/Team:Slovenia/Results" target="_self">Activated TLR vaccine</a>
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Revision as of 16:43, 26 October 2008

Igem-logo-900x200-1-2.jpg



Abstract


Immunobricks


Almost half of the world population is infected with bacteria Helicobacter pylori which is also recognized as a type I carcinogen by WHO. Effective vaccine against H.pylori is not available, although it would be a durable solution, particularly in a formulation affordable to the third world population. H.pylori evades the immune surveillance by modifying several of its components to avoid detection by several Toll-like receptors. Recent discoveries demonstrate that synergy between innate and adaptive immune response is essential for an effective vaccine. We used principles of synthetic biology to assemble well defined synthetic vaccine, composed of the functional “immunobricks”, which combine the activation of innate immune receptors, appropriate cellular localization for processing of antigens and antigenic segments to stimulate formation of antibodies and cellular adaptive response. Our engineered vaccine was implemented in three different types of vaccines based on recombinant protein, engineered bacteria and genetic vaccine.





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