Team:Slovenia/Project

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Revision as of 21:01, 27 October 2008


The problem Modern vaccines Motivation Engineered flagellin vaccine Antigen-TLR fusion vaccine Engineered flagellin vaccine Antigen-TLR fusion vaccine "Real-life" results Biobricks Methods Safety Timeline References

The project

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+<li><a href="https://2008.igem.org/Team:Slovenia" target="_self" ><img src="https://static.igem.org/mediawiki/2008/b/b7/Home_btn.gif" width="64" height="30" border="0" /></a></li>
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+<li><a href="https://2008.igem.org/Team:Slovenia/Background" target="_self" onmouseover="mopen('m1')" onmouseout="mclosetime()"><img src="https://static.igem.org/mediawiki/2008/c/ca/Background_btn.gif" width="138" height="30" border="0" /></a>
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-		<a href="https://2008.igem.org/Team:Slovenia/Background" target="_self">Introduction</a>
+		<a href="https://2008.igem.org/Team:Slovenia/The_problem" target="_self">The problem</a>
-		<a href="https://2008.igem.org/Team:Slovenia/Background" target="_self">Immune response</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Modern_vaccines" target="_self">Modern vaccines</a>
-		<a href="https://2008.igem.org/Team:Slovenia/Background" target="_self">Modern vaccines</a>
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-	<li><a href="https://2008.igem.org/Team:Slovenia/Project" target="_self" onmouseover="mopen('m2')" onmouseout="mclosetime()"><img src="https://static.igem.org/mediawiki/2008/2/23/Project_btn.gif" width="140" height="30" border="0" /></a>
+<li><a href="#" target="_self" onmouseover="mopen('m2')" onmouseout="mclosetime()"><img src="https://static.igem.org/mediawiki/2008/2/23/Project_btn.gif" width="138" height="30" border="0" /></a>
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-		<a href="https://2008.igem.org/Team:Slovenia/Project" target="_self">The idea</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Motivation" target="_self">Motivation</a>
-		<a href="https://2008.igem.org/Team:Slovenia/Project" target="_self">TLR 5</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Engineered_flagellin_vaccine" target="_self">Engineered flagellin vaccine</a>
-		<a href="https://2008.igem.org/Team:Slovenia/Project" target="_self">TLR 3, TLR 4</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Antigen-TLR_fusion_vaccine" target="_self">Antigen-TLR fusion vaccine</a>
-		<a href="https://2008.igem.org/Team:Slovenia/Project" target="_self">Experiment`s on laboratory mice</a>
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-	<li><a href="https://2008.igem.org/Team:Slovenia/Results" target="_self" onmouseover="mopen('m3')" onmouseout="mclosetime()"><img src="https://static.igem.org/mediawiki/2008/4/49/Results_btn.gif" width="99" height="30" border="0" /></a>
+<li><a href="https://2008.igem.org/Team:Slovenia/Results" target="_self" onmouseover="mopen('m3')" onmouseout="mclosetime()"><img src="https://static.igem.org/mediawiki/2008/4/49/Results_btn.gif" width="96" height="30" border="0" /></a>
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-		<a href="https://2008.igem.org/Team:Slovenia/Results" target="_self">Engineered flagellin vaccine</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Engineered_flagellin_vaccine" target="_self">Engineered flagellin vaccine</a>
-		<a href="https://2008.igem.org/Team:Slovenia/Results" target="_self">Activated TLR vaccine</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Antigen-TLR_fusion_vaccine" target="_self">Antigen-TLR fusion vaccine</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Real-life_results" target="_self">"Real-life" results</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Biobricks" target="_self">Biobricks</a>
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-<li><a href="https://2008.igem.org/Team:Slovenia/Biobricks" target="_self" ><img src="https://static.igem.org/mediawiki/2008/b/bd/Biobricks_btn.gif" width="112" height="30" border="0" /></a>
+<!-- tukaj je slika menija conclusion -->
-<li><a href="https://2008.igem.org/Team:Slovenia/Notebook" target="_self" ><img src="https://static.igem.org/mediawiki/2008/8/8e/Notebook_btn.gif" width="117" height="30" border="0" /></a>
+<li><a href="https://2008.igem.org/Team:Slovenia/Conclusions" target="_self" ><img src="https://static.igem.org/mediawiki/2008/b/bd/Biobricks_btn.gif" width="138" height="30" border="0" /></a></li>
-<li><a href="https://2008.igem.org/Team:Slovenia/Sponsors" target="_self" ><img src="https://static.igem.org/mediawiki/2008/d/d4/Sponsors_btn.gif" width="105" height="30" border="0" /></a>
+<!-- konec slike menija conclusion -->
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+		<div id="m4" onmouseover="mcancelclosetime()" onmouseout="mclosetime()">
+		<a href="https://2008.igem.org/Team:Slovenia/Methods" target="_self">Methods</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Safety" target="_self">Safety</a>
+		<a href="https://2008.igem.org/Team:Slovenia/Timeline" target="_self">Timeline</a>
+		<a href="https://2008.igem.org/Team:Slovenia/References" target="_self">References</a>
+		</div>
+	</li>
+<li><a href="https://2008.igem.org/Team:Slovenia/Team" target="_self" ><img src="https://static.igem.org/mediawiki/2008/7/73/Team_btn.gif" width="109" height="30" border="0" /></a></li>
+<li><a href="https://2008.igem.org/Team:Slovenia/Sponsors" target="_self" ><img src="https://static.igem.org/mediawiki/2008/d/d4/Sponsors_btn.gif" width="103" height="30" border="0" /></a>
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-<font size="-1" color="#C73E4A"><i><b>Abstract</b></i></font>
+<font size="-1" color="#C73E4A"><i><b>The project</b></i></font>
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-'''Immunobricks'''
-Almost half of the world population is infected with bacteria ''Helicobacter pylori'' which is also recognized as a type I carcinogen by WHO. Effective vaccine against ''H.pylori'' is not available, although it would be a durable solution, particularly in a formulation affordable to the third world population.'' H.pylori'' evades the immune surveillance by modifying several of its components to avoid detection by several Toll-like receptors. Recent discoveries demonstrate that synergy between innate and adaptive immune response is essential for an effective vaccine. We used principles of synthetic biology to assemble well defined synthetic vaccine, composed of the functional “immunobricks”, which combine the activation of innate immune receptors, appropriate cellular localization for processing of antigens and antigenic segments to stimulate formation of antibodies and cellular adaptive response. Our engineered vaccine was implemented in three different types of vaccines based on recombinant protein, engineered bacteria and genetic vaccine.
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