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Team:Edinburgh/ELSI
From 2008.igem.org
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Revision as of 21:43, 27 October 2008
Contents |
Ethical, Legal and Social Implications
As we consider the ethical, legal and social implications of our project, we should bear in mind the uses which we envision for Micromaize:
- As a biofuel, freeing up land currently being used for biocrops for the growth of food crops.
- As animal feed, freeing up food for human consumption. Additionally, by using our starch as a biofuel or feeding it to animals, we could potentially allow more fertile land (e.g. rainforests) to remain in its natural state instead of being converted for the growth of monocultures.
- As food for humans, but only in the most extreme of circumstances (i.e. famine).
We can divide ethical, legal and social issues into the following categories:
- Safety
- Security
- Cultural, economic and environmental concerns
- Ownership, sharing and innovation
Safety
Research
- The organisms involved in our experiments are not hazardous to humans or animals under normal circumstances. A safety assessment was completed and approved for our research project.
Production
- We envision producing starch by fermentation, which involves culturing cells in a contained environment. Safety requirements and regulations for contained processes are a lot less strict than those in place for uncontained systems.
- Organisms are bound to escape when large quantities of them are present, even in a contained environment. However, our E. coli strain (JM109) is much safer and less potent than organisms naturally present in the environment (which are there by the grace of natural selection). The JM109 strain of E. coli:
- Has multiple disabling mutations,
- Will not colonise the human gut,
- But divides slowly.
- Hence, we are considering using an alternative organism - Bacillus subtilis as our final host. B. subtilis is not pathogenic and generally regarded very positively.
Consumption
- The final product will be safe for consumption. E. coli can be killed very easily – by simply drying it out. Bacillus subtilis is hard to kill but non-pathogenic; in fact, it is currently consumed as a dietary supplement.
- All bacteria contain high levels of RNA, which causes gout. Hence, we envision using the RNAse system developed by the UC Berkeley iGEM team last year to degrade bacterial RNA.
- Concerns amongst the European populace about GM products causing prion diseases are unfounded: prions responsible for BSE, etc. originate in animals, not bacteria or plants.
Security
- 'Could our organisms be employed to degrade forests or houses?' No:
- There are many cellulose-degrading organisms in the wild which have evolved to be much more adept at the task than our recombinant E. coli or B. subtilis. If plants are able to withstand bacteria and fungi which naturally degrade cellulose, then our organisms should not pose a threat.
- Wood contains large quantities of lignin so it is not susceptible to bacterial cellulose degradation.
Cultural, economic and environmental concerns
- Considering people's gut reaction to 'food made from waste products', we must make Micromaize as attractive as possible. Thus, we envision an orange-coloured, citrus-flavoured product thanks to the presence of beta carotene and limonene.
- Monocultures will not be necessary: anything and everything contains cellulose, so farmers will be free to grow whatever they wish.
- Our product is not intended to replace food for humans but to make use of agriculture's waste products and to supplement normal food in times of crisis. Hence, there is no reason why starch-producing bacteria should have any impact on farmers.
Ownership, sharing and innovation
No patent may be filed since we have already released our research into the public domain. However, if a company improves the process we have developed, then we cannot stop them from patenting their innovation.
Acknowledgements
We would like to thank Ms Jane Calvert for her ELSI-related suggestions.
