Team:NYMU-Taipei

From 2008.igem.org

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<dt>Banner</dt>
<dt>Banner</dt>
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<span><img src="http://igem.ym.edu.tw/private2008/images/9/93/NYMU_Bannerinpic_700px.png" width="700" alt="BacToKidney - Toward a better quality of life"></span>
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<span><img src="/wiki/images/9/93/NYMU_Bannerinpic_700px.png" width="700" alt="BacToKidney - Toward a better quality of life"></span>
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Latest revision as of 02:41, 29 October 2008


Banner
pH Sensor
pH Sensor
A sensor of proton concentration (pH). Activates in a high pH environment.
Attachment
Attachment
Attachment to the small intestine.
Urea
Clearance of Urea
A Urea clearance device.
Guanidine
Clearance of Guanidine
The device managing the clearance of guanidino compounds.
Phosphate
Clearance of Phosphate
A Phosphate clearance and balance device.
Time Regulation
Time Regulation
Using oscillators to measure time, it enables detachment from the small intestine after a certain amount of time.



BacToKidney - Toward a better quality of life.


Goal:

  • Use designer bacteria to replace a hemodialysis machine to remove (filter out) toxic waste for treating kidney failure.


Why is it an interesting problem?

  • Approximately 1.3 million people globally have chronic kidney failure that requires either renal transplantation or dialysis - for such patients, the established treatment is hemodialysis
  • The mortality rate of patients undergoing maintenance hemodialysis remains unacceptably high.
  • An extremely high morbidity and a relatively low quality of life (due in part to a high level of dependence and unemployment) and high cost have also been observed.


Our Design:

  • After ingesting our BacToKidney capsule, it passes the through stomach without taking any action, nor being digested, and proceeds to the small intestine. Once in the small intestine, the pH Sensor detects the change in pH and activates the clearance processes of Urea, Phosphate, and Guanidine from the body. To allow itself more time to perform its tasks, the pH Sensor also activates the Attachment process, making the capsule attach itself to the small intestine. After a pre-selected amount of time has passed (controlled by the time regulating oscillators), the capsule detaches itself from the small intestine and exits the body.


The parts our project is made up of:

News and Updates.
  • 2008-10-28: Gradually migrating the wiki pages to here.
  • 2008-08-12: The team page now displays us.
  • 2008-08-06: New Wikipage design put up!
  • 2008-08-01: Wikipage Online!

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