It is seen from the cascading pathway (above) how the gene A-E is not synthesized as repressor gene attaches with the promoter. The pathway starts from autoinducer receptor.
Low cell density (V.Cholera)
The cascading pathway(above) is similiar to the one of V.harveyi but with a slight difference. In V.Cholera HapR i.e. the promoter site is not intact with the repressor gene thus transcription of virulence takes place.