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Team:University of Sheffield /Project
From 2008.igem.org
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Contents |
Overall project
Project Overview
The aim is to engineer a biological machine that will sense microbial contamination of drinking water using quorum sensing. Quorum sensing systems use sensing proteins in the membrane (histidine-kinases in this case) to detect molecules excreted by the bacteria’s own species. After detection in the membrane, a phosphate signal is passed down pathway, causing a DNA regulatory effect. Each species also has its own corresponding quorum-producing protein. In Vibrio cholerae the sensing protein is CqsS and the quorum-producing protein CqsA, and in Legionella they are LqsS and LqsA.
History of development
- Early Brainstorming & Other Crazy Ideas
- A Selected Primary Idea: Sensing Pathogens & Biochip
- v1.0: A completed Design Proposal & Basic Model
- The final proposal: The hybrid-hybrid Sensor
Project Details
| Parts submitted to the Registry |
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| Modelling |
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