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For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.
- First by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location using 3D holography.
- Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein.
- Finally, when our bacteria are stationary in the correct location, the biomaterial production is triggered. These biomaterials can self-assemble to form a 3D bio-scaffold.
Applications of our Biofabricator range from regenerative tissue engineering to Bio-Couture.
Please continue on to our project pages - you may want to start with our >>> Project Specifications >>>
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