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Team:University of Sheffield /Modelling
From 2008.igem.org
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Sam's Model
A mathematical model for the BarA/ UvrY and fluorescence of GFP two-component system is presented and its dynamics behaviour is analysed. The BarA / UvrY regulate the expression of the GFP in E-coil. The model is validated in a two steps:
(i) The signal transduction (ii) The gene expression.
To survive, bacteria monitors their environment constantly and adapt to changing conditions immediately and bacteria have an established signal transduction systems to execute adaptive responses to changing environmental conditions. The signal transduction systems contain of two protein components: a sensor kinase anchored in the cytoplasmic membrane, and a cytoplasmic response regulator that mediates an adaptive response, that is the gene expression.
