Team:NYMU-Taipei

Goal:

• Use designer bacteria to replace a hemodialysis machine to remove (filter out) toxic waste for treating kidney failure.

Why is it an interesting problem?

• Approximately 1.3 million people globally have chronic kidney failure that requires either renal transplantation or dialysis - for such patients, the established treatment is hemodialysis
• The mortality rate of patients undergoing maintenance hemodialysis remains unacceptably high.
• An extremely high morbidity and a relatively low quality of life (due in part to a high level of dependence and unemployment) and high cost have also been observed.

How our project is divided:

• pH Sensor
  • A sensor of proton concentration (pH)
• Attachment
  • An Attachment anchor that attaches to the small intestine
• Clearance of Urea
  • A Urea clearance device
• Clearance of Phosphate
  • A Phosphate clearance and balance device
• Clearance of Guanidine
  • A Guanidine clearance device
• Time Regulation
  • Enables detachment from the small intestine after a certain amount of time
  • Experimenting with two systems:
    • Cyanoxilator: A tuneable cyanobacterial natural (sinusoidal) oscillator implemented in E. coli.
    • Reloxilator: A tuneable intracell-synchronized relaxation oscillator.

• 2008-10-28: Gradually migrating the wiki pages to here.
• 2008-08-12: The team page now displays us.
• 2008-08-06: New Wikipage design put up!
• 2008-08-01: Wikipage Online!