Team:Valencia/Modeling

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Oxidative phosphorylation coupled with thermogenine expression model

Our project tries to implement a controlled heating system inside Saccharomyces cerevisiae. The main variables to be taken into account are temperature production and ATP flow. We need to formulate an effective model for the oxidative phosphorylation that couples the genetic expression of the thermogenine with the efficiency of the respiratory chain in ATP production. It will allow us to evaluate the effect on the energy flow produced by the thermogenic activity.

Notwithstanding the lack of a specific respiratory chain model in yeast, we are trying to develop our differential equations based on kinetic data collected from the literature. We will later compare our model with other sets of differential equations thought to describe the behavior of skeletal muscle mitochondrion.

References

Mitochondrial Respiration and ATP Production Are Significantly Impaired in Striatal Cells Expressing Mutant Huntingtin*

Tamara Milakovic and Gail V. W. Johnson