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From 2008.igem.org

Contents 1 Transportation Efficiency of PIT and PST system 2 Phosphate Concentrations of normal and CKD patient 3 Simulation of Phosphate Absorption 3.1 PST alone in high phosphate condition

Transportation Efficiency of PIT and PST system

[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=6998957 Characterization of two genetically separable inorganic phosphate transport systems in Escherichia coli, JB 1980 (G R Willsky and M H Malamy)] high affinity-low velocity Pst (phosphate specific transport) system have a Km of 0.43 +/- 0.2 microM Pi and a Vmax of 15.9 +/- 0.3 nmol of Pi (mg [dry weight]-1min-1) low affinity-high velocity Pit (Pi transport) system have a Km of 38.2 +/- 0.4 microM and a Vmax of 55 +/- 1.9 nmol of Pi (mg [dry weight]-1min-1)

Phosphate Concentrations of normal and CKD patient

• Normal adult (0.81 to 1.45 mmol/L)
• Chronic Kidney Disease (CDK) patient (1.29 to 2.096 mmol/L)
• [http://www.merck.com/mmpe/sec12/ch156/ch156h.html Disorders of Phosphate Concentration by merck]

Simulation of Phosphate Absorption

• assume 1g/L (dry weight) therapeutic bacteria in the human intestine

PST alone in high phosphate condition

PST system alone can reduce the environmental phosphate from 2000nmol to 100nmol within 2 hours

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