Team:Chiba/Sender

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Signal molecule sender

Design

Sender switch Chiba.jpg

Each species has their own LuxI-type proteins,which synthesize their specific autoinducers,AHLs.AHLs produced by different LuxI-type proteins differ only in the length of the acyl-chain moiety and substitution at position C-3.LuxR,which is original for Vibrio fischeri,is activated by its cognate autoinducer,3OC6HSL.However,LuxR is also activated by non-endogenous molecules,C4HSL,C6HSL,and 3OC12HSL.Activation by non-endogenous molecules requires a higher signal concentration(2).This results in slower activation of receivers,when AHL concentration is increasing.

Fig.4 AHL varieties


AHLsおよびその合成酵素

Strain AHL LuxI-type protein
P.aeruginosa C4HSL, C6HSL RhlI
V. fisheri 3OC6HSL LuxI
P.aeruginosa 3OC12HSL LasI


Experiment

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