University of Sheffield/18 July 2008

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Home The Team The Project Parts submitted to the Registry Modelling Notebook



Meeting Shef.png
Low cell density (V.harveyi)
It is seen from the cascading pathway (above) how the gene A-E is not synthesized as repressor gene attaches with the promoter. The pathway starts from autoinducer receptor.
Meeting Shef1.png
Low cell density (V.Cholera)
The cascading pathway(above) is similiar to the one of V.harveyi but with a slight difference. In V.Cholera HapR i.e. the promoter site is not intact with the repressor gene thus transcription of virulence takes place.


Conclusion

As we intend to modify the E-Coli in a way so that its receptor can sense V.Cholera & Legionella. The problem here is both V.Cholera and Legionella have cascading pathways where reactions take place in a series of steps whereas in E.Coli all reactions are simultaneous. So we might have to introduce TWO plasmids in E.Coli to perform the job.

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