Team:Caltech
From 2008.igem.org
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===The large intestine: an ideal bioreactor=== | ===The large intestine: an ideal bioreactor=== | ||
+ | [[Image:Digestive system diagram en.svg.png|thumb|200px|right|The human digestive tract]] | ||
+ | Talk about the colon | ||
+ | {{clear}} | ||
===Probiotic bacteria and other natural examples=== | ===Probiotic bacteria and other natural examples=== | ||
+ | [[Image:Lacbr.jpg|thumb|right|Electron micrograph of ''Lactobacillus brevis'', a probiotic lactic acid bacterium]] | ||
+ | Talk about probiotics | ||
+ | {{clear}} | ||
===Nissle 1917: Probiotic, commercially available ''E. coli''=== | ===Nissle 1917: Probiotic, commercially available ''E. coli''=== | ||
- | [[Image:packshot_mutaflor.jpg|thumb|Mutaflor - | + | [[Image:packshot_mutaflor.jpg|thumb|right|Mutaflor - a commercially available preparation of Nissle 1917]] |
+ | Talk about Nissle 1917 | ||
{{clear}} | {{clear}} |
Revision as of 21:18, 22 August 2008
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The big ideaWe aim to engineer a probiotic bacterium to improve its medical applications. Our work focuses on four main areas: (1) pathogen defense, either by expression of pathogen-specific bacteriophage or by targeted bursts of reactive oxygen species; (2) vitamin over-expression and delivery; (3) treatment of lactose intolerance, by preferentially metabolizing lactose and funneling it to vitamin production; and (4) regulation of these three treatment functions to produce subpopulations specialized for each function. Why engineer gut microbes?The large intestine: an ideal bioreactorTalk about the colon Probiotic bacteria and other natural examplesTalk about probiotics Nissle 1917: Probiotic, commercially available E. coliTalk about Nissle 1917 For more details, please see our project page. |