Team:Caltech
From 2008.igem.org
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==The big idea== | ==The big idea== | ||
[[Image:Gut_flora_color.png|right|thumb|200px|Engineered gut flora]] | [[Image:Gut_flora_color.png|right|thumb|200px|Engineered gut flora]] | ||
- | We aim to engineer a probiotic bacterium to improve its medical applications. Our work focuses on four main areas: (1) pathogen defense, either by expression of pathogen-specific bacteriophage or by targeted bursts of reactive oxygen species; (2) vitamin over-expression and delivery; (3) treatment of lactose intolerance, by | + | We aim to engineer a probiotic bacterium to improve its medical applications. Our work focuses on four main areas: (1) pathogen defense, either by expression of pathogen-specific bacteriophage or by targeted bursts of reactive oxygen species; (2) vitamin over-expression and delivery; (3) treatment of lactose intolerance, by cleaving lactose to allow absorption in the large intestine; and (4) regulation of these three treatment functions to produce subpopulations specialized for each function. |
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Revision as of 20:49, 8 September 2008
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The big ideaWe aim to engineer a probiotic bacterium to improve its medical applications. Our work focuses on four main areas: (1) pathogen defense, either by expression of pathogen-specific bacteriophage or by targeted bursts of reactive oxygen species; (2) vitamin over-expression and delivery; (3) treatment of lactose intolerance, by cleaving lactose to allow absorption in the large intestine; and (4) regulation of these three treatment functions to produce subpopulations specialized for each function. Why engineer gut microbes?The large intestine: an ideal bioreactorTalk about the colon Probiotic bacteria and other natural examplesTalk about probiotics Nissle 1917: Probiotic, commercially available E. coliTalk about Nissle 1917 For more details, please see our project page. |