Team:Imperial College

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!align="center"|[[Team:Imperial_College|Home]]
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!align="center"|[[Team:Imperial_College/Team|The Team]]
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!align="center"|[[Team:Imperial_College/Project|The Project]]
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For the 2008 iGEM competition, the Imperial College team is working on the foundations for a bioprinter. We are using the Gram-positive ''Bacillus subtilis'' bacterium as a chassis (for a variety of reasons) and hope to be able to exert fine control over its movement via a recently-discovered clutch mechanism. Using light as a stimulus to localise the bacteria, we then intend to trigger production and secretion of a biomaterial in a set pattern. The project was inspired by 3D printers used in fabrication of prototypes for manufacturing, and our "blue-sky" aim is to make a 3D bioprinter!<br clear="all">
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<html><center><img width="830px" src="https://static.igem.org/mediawiki/2008/9/94/Imperial_2008_Title.png"></center><font size="4pt"></html><center>'''<br>For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium ''Bacillus subtilis'' as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.'''<br><br><html></font>
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<!--<td style="text-align:center;"><br><i><font size="3pt" style="border:2px solid;padding:7px;"><b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/BioBricks">45 B. subtilis BioBricks submitted!</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;"><b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Major_Results">BioBrick Characterisation</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;"><b>Chassis Characterisation</b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;">Cell <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Motility">motility tracking</a></b></font><br><br><font size="3pt" style="border:2px solid;padding:7px;">Extensive <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Dry_Lab">modelling</a></b></font></i>-->
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</td></tr></table><br><hr><center><font size="4pt" style="border:0px solid;padding:10px;">Pushed for time? <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Summary">Project Summary</a> | <a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Summary#Results">Achievements</a> | Growing Clothes: <b><a target="_blank" href="https://2008.igem.org/Team:Imperial_College/Cellulose">BioCouture</a></b></font></center><hr><br></html>
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{{Imperial/Box1|'''<html><font size=6px>Overview</font></html>'''|
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The following video is a simplified representation of how we want our system to work...
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*First by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location using 3D holography.
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*Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein.
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*Finally, when our bacteria are stationary in the correct location, the biomaterial production is triggered. These biomaterials can self-assemble to form a 3D bio-scaffold.
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The Imperial College 2008 iGEM team is made up of 9 students (5 undergraduate bioengineers, 3 graduate biochemists and 1 graduate biologist), 4 advisors and two professors. You can find out more about the team members at the [[Team:Imperial_College/Team | team page]].<br clear="all">
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'''<html><center><font size=4px></html>Please continue on to our project pages - you may wish to start with our [[Team:Imperial_College/Project |>>> Project Specifications >>>''']]<html></font></center></html>
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[[Team:Imperial_College | Imperial College]]
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The Imperial College Team 2008 has received sponsorship from a number of generous companies. We are grateful for their kind support.
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<html><center><a href="http://www.bio-rad.com/"><img height="40px" src="http://i59.photobucket.com/albums/g305/Timpski/Biorad.png"></a><a href="http://www.fisher.co.uk/"><img height="50px" src="http://i59.photobucket.com/albums/g305/Timpski/Fisher.png"></a><a href="http://www.geneart.com/"><img height="25px" src="http://i59.photobucket.com/albums/g305/Timpski/Geneart.png"></a><a href="http://www.vwr.com/index.htm"><img height="50px" src="http://i59.photobucket.com/albums/g305/Timpski/VWR.png"></a></center>
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<center>We would also like to thank the members of the Center for Structural Biology for their help and support during our iGEM project.</center></html>
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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
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Latest revision as of 09:06, 30 October 2008



For the 2008 iGEM competition, the Imperial College Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis as our chassis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger.

Pushed for time? Project Summary | Achievements | Growing Clothes: BioCouture

Overview

The following video is a simplified representation of how we want our system to work...

  • First by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location using 3D holography.
  • Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein.
  • Finally, when our bacteria are stationary in the correct location, the biomaterial production is triggered. These biomaterials can self-assemble to form a 3D bio-scaffold.


Please continue on to our project pages - you may wish to start with our >>> Project Specifications >>>


The Imperial College Team 2008 has received sponsorship from a number of generous companies. We are grateful for their kind support.

We would also like to thank the members of the Center for Structural Biology for their help and support during our iGEM project.


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