Team:Paris/Network analysis and design/System improvements

From 2008.igem.org

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| style="background: #D4E2EF;"|Core system
| style="background: #D4E2EF;"|Core system
| Figure core system
| Figure core system
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| Liks core system
| Liks core system
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| style="background: #D4E2EF;" |Modular system
| style="background: #D4E2EF;" |Modular system
| Figure modular system
| Figure modular system
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| [[Image:orgstar.GIF]][[Image:orgstar.GIF]]
| Links Garcia-Ojalvo
| Links Garcia-Ojalvo
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| style="background: #D4E2EF;" |Resulting system
| style="background: #D4E2EF;" |Resulting system
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| Figure resulting system
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| [[Image:orgstar.GIF]][[Image:orgstar.GIF]][[Image:orgstar.GIF]]
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| Links resulting
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!colspan="4"  | System Improvements: synchronized oscillations should be given by S2.
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!colspan="4"  | Synchronized oscillations should be given by S2.
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Core system does not oscillate. How can we enhance it?
Core system does not oscillate. How can we enhance it?

Revision as of 22:14, 25 October 2008

System Improvements


Name Description Evaluation Links
Core system Figure core system Non.PNG Liks core system
Modular system Figure modular system File:Orgstar.GIFFile:Orgstar.GIF Links Garcia-Ojalvo
Resulting system Figure resulting system File:Orgstar.GIFFile:Orgstar.GIFFile:Orgstar.GIF Links resulting
Synchronized oscillations should be given by S2.


Core system does not oscillate. How can we enhance it?

We need a 'delay' so we can:

1 add more genes to the circuit

2 use quorum sensing (qs)

we chose quorum sensing that can allowed both 'delay' and population synchonization. two ways to add it:

  • S4: Inspired from Garcia-Ojalvo: oscillating repressilator + oscillating qs module = synchronized oscillations
  • S2: it amounts to replace single interaction by more complex interactions: should create delay

we analyze both systems for their capacity to generate oscillations. S2 seems more promising. Thus we further analize S2 for its capacity to generate synchrionized oscillations.