Team:Paris/Network analysis and design/System improvements

From 2008.igem.org

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| style="background: #D4E2EF;" |Modular system
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| style="background: #D4E2EF;" |Bimodular system
| Figure modular system
| Figure modular system
| [[Image:Damped.jpg]]
| [[Image:Damped.jpg]]
| Links Garcia-Ojalvo
| Links Garcia-Ojalvo
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| style="background: #D4E2EF;" |Resulting system
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| style="background: #D4E2EF;" |Unimodular system
| Figure resulting system
| Figure resulting system
| [[Image:Oscillating.jpg]]
| [[Image:Oscillating.jpg]]
| Links resulting
| Links resulting
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!colspan="4"  | Synchronized oscillations should be given by S2.
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!colspan="4"  | Synchronized oscillations should be given by the unimodular system.
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Revision as of 11:25, 29 October 2008

System Improvements


Name Description Evaluation Links
Core system Figure core system File:Equilibrium.jpg Links core system
Bimodular system Figure modular system File:Damped.jpg Links Garcia-Ojalvo
Unimodular system Figure resulting system File:Oscillating.jpg Links resulting
Synchronized oscillations should be given by the unimodular system.


Core system does not oscillate. How can we enhance it?

We need a 'delay' so we can:

1 add more genes to the circuit

2 use quorum sensing (qs)

we chose quorum sensing that can allowed both 'delay' and population synchonization. two ways to add it:

  • S4: Inspired from Garcia-Ojalvo: oscillating repressilator + oscillating qs module = synchronized oscillations
  • S2: it amounts to replace single interaction by more complex interactions: should create delay

we analyze both systems for their capacity to generate oscillations.

S2 seems more promising.

Thus we further analize S2 for its capacity to generate synchrionized oscillations (using different initial concentrations and cell populations variability).