# Team:Purdue/Modeling

### From 2008.igem.org

## Modeling Objectives

- Develop a mechanistics ODE model of the population to predict gene expression dynamics
- Question? .... Will the color production be fast enough to be useful to the user? Or will it be too late?
- What is the relationship between UV exposure and reporter gene expression?
- Can we construct a useful calibration curve of color as a function of UV?

## Modeling References

- 1997. "Mathematical model of the SOS response regulation of an excision repair deficient mutant of
*Escherichia coli*after UV light irradation". [1]. Off-the-shelf mechanistic model of the SOS response. Utilized as the basic model for our system.

- 2005. "Response times and mechanisms of SOS induction by attaching promoters to GFP: "Precise Temporal Modulation in the Response of the SOS DNA Repair Network in Individual Bacteria" [2]. Potential Validation Data Set. Model should predict similar dynamics.

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