Team:Slovenia/Conclusions
From 2008.igem.org
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- | <strong>Achievements<br /><br /></strong> | + | <strong>Achievements <br /><br /></strong> |
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- | <li>We have demonstrated the power of modular building blocks approach of synthetic biology (IMMUNOBRICKS) for the rational design of vaccines</li> | + | <li>We have demonstrated <b>the power of modular building blocks approach of synthetic biology (IMMUNOBRICKS)</b> for the rational design of vaccines</li> |
- | <li>We have designed a new type of vaccine against <i>H. pylori</i> based on the chimeric flagellin that combines activation of innate and adaptive immunity within the same molecule | + | <li>We have designed a new type of vaccine against <i>H. pylori</i> based on the chimeric flagellin that <b>combines activation of innate and adaptive immunity within the same molecule</b> |
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<li>Chimeric flagellins were produced in bacteria, purified and characterized</li> | <li>Chimeric flagellins were produced in bacteria, purified and characterized</li> | ||
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<li>Antigen-TLR fusions are functional and their localization can be modulated by the selection of transmembrane segment</li> | <li>Antigen-TLR fusions are functional and their localization can be modulated by the selection of transmembrane segment</li> | ||
<li>Various DNA vaccine constructs have been successfully introduced by electroporation intramuscularly or subcutanelously and expression of the fusion protein in the target tissue <i>in vivo</i> was demonstrated</li> | <li>Various DNA vaccine constructs have been successfully introduced by electroporation intramuscularly or subcutanelously and expression of the fusion protein in the target tissue <i>in vivo</i> was demonstrated</li> | ||
- | <li>Two chimeric recombinant protein vaccines showed intense IgG antibody response in mice and immunized sera also reacted with live and heat-killed <i>H. pylori</i> | + | <li>Two chimeric recombinant protein vaccines showed <b>an intense IgG antibody response in mice</b> and <b>immunized sera also reacted with live and heat-killed <i>H. pylori</i><b> implying that they recognize epitopes of <i>H. pylori</i>.</li> |
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Revision as of 00:49, 30 October 2008
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Achievements
What remains to be done ?
Prospects
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